1. Neuronal Signaling
  2. Amyloid-β
  3. Hoechst 34580

Hoechst 34580 (Synonyms: HOE 34580)

Cat. No.: HY-15560 Purity: 99.84%
Handling Instructions

Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei.

For research use only. We do not sell to patients.

Hoechst 34580 Chemical Structure

Hoechst 34580 Chemical Structure

CAS No. : 23555-00-2

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10 mg USD 108 Get quote
50 mg USD 288 Get quote
100 mg USD 408 Get quote

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Description

Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei.

IC50 & Target

Amyloid-β[1]

In Vitro

Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580[1].

Molecular Weight

451.57

Formula

C₂₇H₂₉N₇

CAS No.

23555-00-2

SMILES

CN1CCN(C2=CC=C3C(N=C(C4=CC=C5C(N=C(C6=CC=C(N(C)C)C=C6)N5)=C4)N3)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (104.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2145 mL 11.0725 mL 22.1450 mL
5 mM 0.4429 mL 2.2145 mL 4.4290 mL
10 mM 0.2214 mL 1.1072 mL 2.2145 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Hoechst 34580
Cat. No.:
HY-15560
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