1. Apoptosis
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  3. Mcl1-IN-9

Mcl1-IN-9 

Cat. No.: HY-128607
Handling Instructions

Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.

For research use only. We do not sell to patients.

Mcl1-IN-9 Chemical Structure

Mcl1-IN-9 Chemical Structure

CAS No. : 1810769-31-3

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Description

Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].

IC50 & Target[1]

Mcl-1

0.03 nM (Ki)

In Vitro

Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1].

In Vivo

Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

639.18

Formula

C₃₇H₃₉ClN₄O₄

CAS No.

1810769-31-3

SMILES

O=C1C2=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=CC=CC(C5=C(C)N(C)N=C5C)=C4N2CCCN1CC6=CC=CC(C(O)=O)=C6

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Mcl1-IN-9
Cat. No.:
HY-128607
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Mcl1-IN-9

Cat. No.: HY-128607