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Cat. No.: HY-128607

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Mcl1-IN-9

Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC₅₀ of 446 nM in reengineered BCR-ABL+ B-ALL cells and a K_i of 0.03 nM.

For research use only. We do not sell to patients.

CAS No.: 1810769-31-3
Formula: C₃₇H₃₉ClN₄O₄
Molecular Weight:639.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Mcl1-IN-9 Chemical Structure

CAS No.: 1810769-31-3

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Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC₅₀ of 446 nM in reengineered BCR-ABL+ B-ALL cells and a K_i of 0.03 nM^[1].

IC₅₀ & Target^[1]

Mcl-1

0.03 nM (Ki)

All Bcl-2 Family Isoforms :

In Vitro

Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1810769-31-3
Molecular Weight 639.18
Formula C₃₇H₃₉ClN₄O₄
SMILES

O=C1C2=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=CC=CC(C5=C(C)N(C)N=C5C)=C4N2CCCN1CC6=CC=CC(C(O)=O)=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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