1. Phenylpropanoids
  2. Biliatresone

Biliatresone 

Cat. No.: HY-119412
Handling Instructions

Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model.

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Biliatresone Chemical Structure

Biliatresone Chemical Structure

CAS No. : 1801433-90-8

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Description

Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model[1].

In Vitro

Biliatresone has a reduction in primary cilia and a dose-dependent decrease in visible microtubules, suggesting that Biliatresone decreases microtubule stability in primary neonatal mouse extrahepatic cholangiocytes[1].
Biliatresone (2 µg/ml; for 24 hours) shows disruption of the spheroid lumen and abnormal cholangiocyte polarity in mouse cholangiocyte[1].

In Vivo

Biliatresone exhibits toxicity at doses of 0.065-1.0 μg/mL with a marked reduction and the lethal dose of Biliatresone in a zebrafish assay is 1 μg/mL[1].
Larvae treated at 5 dpf with low doses of biliatresone [0.0625 µg/ml (0.2 µM) and 0.125 µg/ml (0.4 µM)] shows only subtle gallbladder defects, whereas larvae treated with higher doses has pronounced morphological defects of the gallbladder and extrahepatic ducts[1].

Molecular Weight

328.32

Formula

C₁₈H₁₆O₆

CAS No.

1801433-90-8

SMILES

C=C(C(C1=C(C=C2OCOC2=C1OC)OC)=O)C3=CC=CC=C3O

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Keywords:

BiliatresoneOtherstoxinextrahepaticbiliaryatresiazebrafishInhibitorinhibitorinhibit

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