1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC

SW-163D-AcLysValCit-PABC-DMAE 

Cat. No.: HY-114325
Handling Instructions

SW-163D-AcLysValCit-PABC-DMAE is a Drug-Linker Conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker.

For research use only. We do not sell to patients.

SW-163D-AcLysValCit-PABC-DMAE Chemical Structure

SW-163D-AcLysValCit-PABC-DMAE Chemical Structure

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SW-163D-AcLysValCit-PABC-DMAE is a Drug-Linker Conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker[1].

IC50 & Target

Drug-Linker Conjugates for ADC[1]

In Vitro

SW-163D is a cyclodepsipeptide antibiotic that is isolated from Streptomyces sp. SW-163D also exhibits antitumour activity. PF06888667 is a potent, stable, and efficacious ADC that consists of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline-p-aminobenzyl alcohol-N,N-dimethylethylenediamine (AcLysValCitPABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase[1].

References
Molecular Weight

1817.05

Formula

C₈₅H₁₁₃N₁₉O₂₂S₂

SMILES

C[[email protected]@H](C(N(C)[[email protected]@H]([[email protected]]1SC)C(N(C)[[email protected]@]2([[email protected]@H](C)C2)C(OC[[email protected]](C(N[[email protected]@H](C)C(N([[email protected]](C(N([[email protected]@]3([[email protected]@H](C)C3)C(OC[[email protected]]4NC(C5=C(OC(N(C)CCN(C)C(OCC6=CC=C(NC([[email protected]](CCCNC(N)=O)NC([[email protected]](C(C)C)NC([[email protected]](NC(C)=O)CCCCN)=O)=O)=O)C=C6)=O)=O)C=C7C(C=CC=C7)=N5)=O)=O)C)=O)CS1)C)=O)=O)NC(C8=C(O)C=C9C(C=CC=C9)=N8)=O)=O)=O)=O)NC4=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
SW-163D-AcLysValCit-PABC-DMAE
Cat. No.:
HY-114325
Quantity:

SW-163D-AcLysValCit-PABC-DMAE

Cat. No.: HY-114325