6-Deoxyjacareubin
Based on 1 Customer Validation
6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 16265-56-8
- Formel: C18H14O5
- Molecular Weight:310.30
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Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
26 μM
Compound: 11
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Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay
Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay
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[PMID: 29475587] |
| HL-60 | IC50 |
2.7 μM
Compound: 11
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Antiproliferative activity against human HL60 cells after 48 hrs by CCK8 assay
Antiproliferative activity against human HL60 cells after 48 hrs by CCK8 assay
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[PMID: 29475587] |
| HSC-2 | CC50 |
0.48 mM
Compound: 18
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Cytotoxicity against human HSC2 cells
Cytotoxicity against human HSC2 cells
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[PMID: 11170668] |
| NIH3T3 | CC50 |
25.3 μM
Compound: 11
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Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by CCK8 assay
Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by CCK8 assay
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[PMID: 29475587] |
6-deoxyjacareubin inhibits cytotoxicity induced by sealed chamber hypoxia (1 % O2) and chemically induced hypoxia (CoCl2) in HEK293T cells and other types of cell lines such as HT1080 (human sarcoma cell line), Neuro2a (mouse neuroblastoma cell line), and MO3.13 (human oligodendrocytic cell line)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male SOD1G93A mice (eight weeks)[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneally (i.p.), every seven days for 1 month
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Result:Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss.
Chemical Information
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CAS. Nr. 16265-56-8
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Appearance Solid
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Molecular Weight 310.30
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Formel C18H14O5
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Color Light yellow to yellow
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SMILES
O=C1C2=C(OC3=C1C=CC=C3O)C=C4C(C=CC(C)(C)O4)=C2O
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
6-Deoxyjacareubin Related Classifications
HY-N2707 Related Classifications
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