2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. 6-Deoxyjacareubin

6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS).

For research use only. We do not sell to patients.

6-Deoxyjacareubin Chemical Structure

6-Deoxyjacareubin Chemical Structure

CAS No. : 16265-56-8

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6-Deoxyjacareubin Related Antibodies

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Description

6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].

In Vitro

6-deoxyjacareubin inhibits cytotoxicity induced by sealed chamber hypoxia (1 % O2) and chemically induced hypoxia (CoCl2) in HEK293T cells and other types of cell lines such as HT1080 (human sarcoma cell line), Neuro2a (mouse neuroblastoma cell line), and MO3.13 (human oligodendrocytic cell line)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Deoxyjacareubin Related Antibodies
In Vivo

6-Deoxyjacareubin (5 mg/kg，腹腔注射，每7天一次，连用1个月) 减轻家族性 ALS 模型小鼠的运动神经元丢失[1]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SOD1G93A mice (eight weeks)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneally (i.p.), every seven days for 1 month
Result: Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss.
Molecular Weight

310.30

Formula

C18H14O5
CAS No.
SMILES

O=C1C2=C(OC3=C1C=CC=C3O)C=C4C(C=CC(C)(C)O4)=C2O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6-Deoxyjacareubin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Deoxyjacareubin16265-56-8Reactive Oxygen SpeciesAmyotrophic lateral sclerosisHEK293T cellslocomotor dysfunctionnon-apoptotic cell deathHT1080MO3.13Neuro2aneurodegenerationInhibitorinhibitorinhibit

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