Hirsutanonol
Hirsutanonol ((5S)-Hirsutanonol) is a diarylheptanoid that can be isolated from the bark of Alnus hirsute var. sibirica. Hirsutanonol inhibits cyclooxygenase-2 (COX-2) expression. Hirsutanonol has anti-filarial with an IC50 value of 44.11 μg/mL for microfilariae.
For research use only. We do not sell to patients.
- CAS No.: 41137-86-4
- Formula: C19H22O6
- Molecular Weight:346.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
17.8 μM
Compound: 2
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess method
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[PMID: 33422907] |
| RAW264.7 | IC50 |
19.3 μM
Compound: 2
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
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[PMID: 33422907] |
| RAW264.7 | IC50 |
21.3 μM
Compound: 2
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
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[PMID: 33422907] |
| RAW264.7 | IC50 |
23.7 μM
Compound: 2
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr followed by LPS stimulation and measured after 18 hrs by immunoassay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr followed by LPS stimulation and measured after 18 hrs by immunoassay
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[PMID: 33422907] |
| RAW264.7 | IC50 |
25.7 μg/mL
Compound: 2
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
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[PMID: 33422907] |
| RAW264.7 | IC50 |
3.8 μM
Compound: 2
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 20 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 20 hrs by Griess assay
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[PMID: 33422907] |
| RAW264.7 | IC50 |
30 μM
Compound: 2
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
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[PMID: 33422907] |
| RAW264.7 | IC50 |
44.3 μg/mL
Compound: 2
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 24 hrs by Griess assay
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[PMID: 33422907] |
| RAW264.7 | IC50 |
9.9 μM
Compound: 2
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB activation incubated for 24 hrs by SEAP microplate reader analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB activation incubated for 24 hrs by SEAP microplate reader analysis
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[PMID: 33422907] |
Chemical Information
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CAS No. 41137-86-4
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Molecular Weight 346.37
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Formula C19H22O6
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SMILES
OC1=C(O)C=CC(CCC(C[C@@H](O)CCC2=CC(O)=C(O)C=C2)=O)=C1
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Synonyms
(5S)-Hirsutanonol
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Lee MW, et al. Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica. Biol Pharm Bull. 2000 Apr;23(4):517-8. [Content Brief]
[2]. Yadav D, et al. Antifilarial diarylheptanoids from Alnus nepalensis leaves growing in high altitude areas of Uttarakhand, India. Phytomedicine. 2013 Jan 15;20(2):124-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hirsutanonol Related Classifications
HY-N4044 Related Classifications
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