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Letosteine is an orally active, potent and safe expectorant. Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research[1][2][3].

For research use only. We do not sell to patients.

Letosteine Chemical Structure

Letosteine Chemical Structure

CAS No. : 53943-88-7

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Based on 1 publication(s) in Google Scholar

Letosteine Related Antibodies

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Description

Letosteine is an orally active, potent and safe expectorant. Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research[1][2][3].

In Vivo

Letosteine (Sprague-Dawley rats, 20 mg/kg, IV or Orally, once) is rapidly excreted with mainly in urine[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats
Dosage: 20 mg/kg
Administration: IV or Orally, once
Result: Rapidly was excreted with mainly in urine. More than 86% of the administered [14C]-radioactivity was recovered in urine within 72 h, 5-7% of the administered [14C]-radioactivity was recovered as 14CO2 in the expired air.
Molecular Weight

279.38

Formula

C10H17NO4S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCOC(CSCCC1NC(C(O)=O)CS1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 11.11 mg/mL (39.77 mM; ultrasonic and adjust pH to 12 with 1M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5794 mL 17.8968 mL 35.7935 mL
5 mM 0.7159 mL 3.5794 mL 7.1587 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5794 mL 17.8968 mL 35.7935 mL 89.4839 mL
5 mM 0.7159 mL 3.5794 mL 7.1587 mL 17.8968 mL
10 mM 0.3579 mL 1.7897 mL 3.5794 mL 8.9484 mL
15 mM 0.2386 mL 1.1931 mL 2.3862 mL 5.9656 mL
20 mM 0.1790 mL 0.8948 mL 1.7897 mL 4.4742 mL
25 mM 0.1432 mL 0.7159 mL 1.4317 mL 3.5794 mL
30 mM 0.1193 mL 0.5966 mL 1.1931 mL 2.9828 mL
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Letosteine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Letosteine53943-88-7OthersBronchopneumopathiesRespiratory diseasesOrally activeInhibitorinhibitorinhibit

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