AF10 Antibody (YA2017)
(Synonyms: MLLT10; AF10; Protein AF-10; ALL1-fused gene from chromosome 10 protein)AF10 Antibody (YA2017) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AF10.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
AF10 Antibody (YA2017) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AF10.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 140 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 113 kDa
Recombinant protein of human AF10 aa788-1050.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
AF10 is a Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Expressed abundantly in testis -
Isoforms & Post-Translational Modification
P55197 has 4 isomers: P55197-4: 113320 Da (predicted); P55197-1: 109026 Da (predicted); P55197-2: 13851 Da (predicted); P55197-3: 20047 Da (predicted).
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Subunit
Self-associates. Interacts with FSTL3 isoform 2; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with YEATS4.
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SwissProt ID
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Synonyms
MLLT10; AF10; Protein AF-10; ALL1-fused gene from chromosome 10 protein
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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