Garbanzol
Based on 1 Customer Validation
Garbanzol is an orally active natural flavonoid compound. Garbanzol is one of the key intermediates in the flavonoid biosynthetic pathway. Garbanzol exhibits anti-mutagenic activity.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 1226-22-8
- Formula: C15H12O5
- Molecular Weight:272.25
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 8
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 18440233] |
| B16-BL6 | IC50 |
>100 μM
Compound: 8
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Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
|
[PMID: 18440233] |
| HeLa | IC50 |
>100 μM
Compound: 8
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 18440233] |
| HT-1080 | IC50 |
>100 μM
Compound: 8
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Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
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[PMID: 18440233] |
| Lewis lung carcinoma cell line | IC50 |
>100 μM
Compound: 8
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Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay
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[PMID: 18440233] |
In Vitro
Garbanzol (0.125-0.250 mg/plate; 48 h) exhibits no antimutagenic activity against aflatoxin B1-induced mutagenicity in Salmonella typhimurium TA100, but shows significant antimutagenic activity against MNNG-induced mutagenicity at 0.125 mg/plate and weak activity at 0.250 mg/plate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Parmacokinetics
| Species | Dose | Route | Cmax | AUC | Tmax | T1/2 | MRT0-t |
|---|---|---|---|---|---|---|---|
| Rat[2] | 1.154 mg/kg | p.o. | 0.24 | 0.41 | 0.60 h | 5.44 h | 2.52 h |
Chemical Information
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CAS No. 1226-22-8
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Appearance Solid
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Molecular Weight 272.25
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Formula C15H12O5
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](C2=CC=C(O)C=C2)OC3=CC(O)=CC=C3C1=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Protocols
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Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Park KY, et al. Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. J Ethnopharmacol. 2004;90(1):73-79. [Content Brief]
[2]. Jin MJ, et al. Pharmacokinetic Profile of Eight Phenolic Compounds and Their Conjugated Metabolites after Oral Administration of Rhus verniciflua Extracts in Rats. J Agric Food Chem. 2015;63(22):5410-5416. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Garbanzol Related Classifications
HY-N3926 Related Classifications
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