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Cat. No.: HY-N3360

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Lupalbigenin

Name: Lupalbigenin
Brand: MedChemExpress
SKU: HY-N3360
Price: 490.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Lupalbigenin is an isoflavonoid compound that can be isolated and extracted from Licorice and Derris scandens. Lupalbigenin exhibits anti-inflammatory, anti-tumor, anti-oxidative stress, anti-metastatic, and anti-dermatophyte effects. Lupalbigenin significantly downregulates key survival factors such as pAKT/AKT, pERK/ERK, and the anti-apoptotic protein BCL-2 in cancer cells, thereby promoting apoptosis. Lupalbigenin is also an insect antifeedant and is toxic to chewing and piercing-sucking insects. Lupalbigenin can be used in cancer and fungal infection research.

For research use only. We do not sell to patients.

Purity : 98%
CAS No.: 76754-24-0
Formula: C₂₅H₂₆O₅
Molecular Weight:406.47

Storage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lupalbigenin Chemical Structure

CAS No.: 76754-24-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

Bcl-2

ERK

Akt

All Endogenous Metabolite Isoforms :

All Bcl-2 Family Isoforms :

All ERK Isoforms :

All Akt Isoforms :

In Vitro

Lupalbigenin promotes detachment-induced cell death and downregulates pAKT/AKT, pERK/ERK, and BCL-2 proteins in human lung cancer cells^[1].
Lupalbigenin has antifungal activity in dermatophytes^[1].
Lupalbigenin has antifeedant and toxic effects in chewing and sucking insects^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 76754-24-0
Appearance Solid
Molecular Weight 406.47
Formula C₂₅H₂₆O₅
Color White to off-white
SMILES

O=C1C2=C(O)C(C/C=C(C)/C)=C(O)C=C2OC=C1C3=CC(C/C=C(C)/C)=C(O)C=C3
Structure Classification
- Flavonoids
- Isoflavones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen M, et al. Exploration in the Mechanism of Action of Licorice by Network Pharmacology. Molecules (Basel, Switzerland). 2019 Aug 15;24(16):2959.

[2]. Fan Z, et al. Heterologous Biosynthesis of Prenylflavonoids in Escherichia coli Based on Fungus Screening of Prenyltransferases. ACS Omega. 2025;10:8891-8900.

[3]. Sarker SD, et al. All about isowighteone and its hydrate. J Nat Prod Discov. 2026;5(4):3898.

[4]. Chen Y, et al. Cytotoxicity and Anti-inflammatory Properties of Apigenin-Derived Isolaxifolin. Journal of natural products. 2019 Sep 27;82(9):2451-2459.

[5]. Mukit TMA, et al. Chemical and biological profiling of Derris scandens (Roxb.) Benth. Bangladesh J Bot. 2024;53(2):227-233.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Lupalbigenin

All Endogenous Metabolite Isoforms

All Bcl-2 Family Isoforms

All ERK Isoforms

All Akt Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Lupalbigenin Related Classifications

HY-N3360 Related Classifications

Bioz

Keywords

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