Art. -Nr.: HY-N0078

Ginkgolic Acid (C13:0)

(Synonyms: Ginkgolic acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic acid)

Kundenbewertung

Based on 1 Customer Validation

Ginkgolic Acid (C13:0) (Ginkgoneolic Acid) is an anti-cariogenic agent and a PI3Kδ inhibitor (IC₅₀: 2.49 μM). Ginkgolic Acid (C13:0) exhibits antibacterial and anti-parasitic activities. Ginkgolic Acid (C13:0) can also inhibit mast cell degranulation (IC₅₀: 2.40 μM).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.92%
CAS. Nr.: 20261-38-5
Formel: C₂₀H₃₂O₃
Molecular Weight:320.47

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Ginkgolic Acid (C13:0) Chemical Structure

CAS. Nr.: 20261-38-5

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[2]

PI3Kδ

2.49 μM (IC₅₀)

Alle PI3K Isoform-spezifische Produkte anzeigen :

Alle Parasite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>50 μg/mL Compound: 7, phenolic acid C13:0	Growth inhibition of human A549 cells after 2 days by SRB assay Growth inhibition of human A549 cells after 2 days by SRB assay	[PMID: 9677265]
CCD-18Co	IC₅₀	59.11 μg/mL Compound: 7, phenolic acid C13:0	Growth inhibition of human CCD-18Co cells after 2 days by SRB assay Growth inhibition of human CCD-18Co cells after 2 days by SRB assay	[PMID: 9677265]
HCT-15	IC₅₀	>50 μg/mL Compound: 7, phenolic acid C13:0	Growth inhibition of human HCT15 cells after 2 days by SRB assay Growth inhibition of human HCT15 cells after 2 days by SRB assay	[PMID: 9677265]
HT1197	IC₅₀	44.64 μg/mL Compound: 7, phenolic acid C13:0	Growth inhibition of human HT1197 cells after 2 days by SRB assay Growth inhibition of human HT1197 cells after 2 days by SRB assay	[PMID: 9677265]
MCF7	IC₅₀	22.67 μg/mL Compound: 7, phenolic acid C13:0	Growth inhibition of human MCF7 cells after 2 days by SRB assay Growth inhibition of human MCF7 cells after 2 days by SRB assay	[PMID: 9677265]
SK-OV-3	IC₅₀	20.4 μg/mL Compound: 7, phenolic acid C13:0	Growth inhibition of human SKOV3 cells after 2 days by SRB assay Growth inhibition of human SKOV3 cells after 2 days by SRB assay	[PMID: 9677265]

In Vitro

Ginkgolic Acid (C13:0) (0-64 μg/mL; 0-24 h) can inhibit and kill S. mutans (MIC: 4 μg/mL; MBC: 8 μg/mL), and also inhibit its adhesion to saliva-coated hydroxyapatite, acid production, and biofilm formation^[1].
Ginkgolic Acid (C13:0) (1-100 μM; 1.5 h) significantly inhibits the release of DNP-BSA-induced β-hexosaminidase in RBL-2H3 mast cells and reduces IgE/BSA-induced mast cell degranulation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ginkgolic Acid (C13:0) (2.5 mg/L; immersion; 48 h) has 100% anthelmintic efficacy in European eels infected with Paradactylogyrus, with an ED₅₀ of 0.72 mg/L^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 20261-38-5
Appearance Solid
Molecular Weight 320.47
Formel C₂₀H₃₂O₃
Color White to off-white
SMILES

O=C(O)C1=C(CCCCCCCCCCCCC)C=CC=C1O
Synonyms

Ginkgolic acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic acid
Structure Classification
- Phenols
- Monophenols
- Ketones, Aldehydes, Acids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (312.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1204 mL

15.6021 mL

31.2042 mL

5 mM

0.6241 mL

3.1204 mL

6.2408 mL

10 mM

0.3120 mL

1.5602 mL

3.1204 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. He J, et al. Effects of ginkgoneolic acid on the growth, acidogenicity, adherence, and biofilm of Streptococcus mutans in vitro. Folia Microbiol (Praha). 2013 Mar;58(2):147-53. [Content Brief]

[2]. Guo JF, et al. Discovery of a natural PI3Kδ inhibitor through virtual screening and biological assay study. Biochem Biophys Res Commun. 2019 Jan 15;508(3):709-714. [Content Brief]

[3]. Wang G X, et al. In vivo assessment of anthelmintic efficacy of ginkgolic acids (C13: 0, C15: 1) on removal of Pseudodactylogyrus in European eel. Aquaculture, 2009, 297(1-4): 38-43.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1204 mL	15.6021 mL	31.2042 mL	78.0104 mL
	5 mM	0.6241 mL	3.1204 mL	6.2408 mL	15.6021 mL
	10 mM	0.3120 mL	1.5602 mL	3.1204 mL	7.8010 mL
	15 mM	0.2080 mL	1.0401 mL	2.0803 mL	5.2007 mL
	20 mM	0.1560 mL	0.7801 mL	1.5602 mL	3.9005 mL
	25 mM	0.1248 mL	0.6241 mL	1.2482 mL	3.1204 mL
	30 mM	0.1040 mL	0.5201 mL	1.0401 mL	2.6003 mL
	40 mM	0.0780 mL	0.3901 mL	0.7801 mL	1.9503 mL
	50 mM	0.0624 mL	0.3120 mL	0.6241 mL	1.5602 mL
	60 mM	0.0520 mL	0.2600 mL	0.5201 mL	1.3002 mL
	80 mM	0.0390 mL	0.1950 mL	0.3901 mL	0.9751 mL
	100 mM	0.0312 mL	0.1560 mL	0.3120 mL	0.7801 mL

Keywords

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Ginkgolic Acid (C13:0)

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Autophagy Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Antibacterial Compound Library

Medicine Food Homology Compound Library

Phenols Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Antiparasitic Compound library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Glucose Metabolism Compound Library

Food-Sourced Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Anti-Rheumatic Arthritis Compound Library

Mass Spectrometry Human Metabolite Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Alle PI3K Isoform-spezifische Produkte anzeigen

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Ginkgolic Acid (C13:0) Related Classifications

HY-N0078 Related Classifications