Ginkgolic Acid (C13:0)
Based on 1 Customer Validation
Ginkgolic Acid (C13:0) (Ginkgoneolic Acid) is an anti-cariogenic agent and a PI3Kδ inhibitor (IC50: 2.49 μM). Ginkgolic Acid (C13:0) exhibits antibacterial and anti-parasitic activities. Ginkgolic Acid (C13:0) can also inhibit mast cell degranulation (IC50: 2.40 μM).
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 20261-38-5
- Formula: C20H32O3
- Molecular Weight:320.47
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
More
Biological Activity
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PI3Kδ 2.49 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μg/mL
Compound: 7, phenolic acid C13:0
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Growth inhibition of human A549 cells after 2 days by SRB assay
Growth inhibition of human A549 cells after 2 days by SRB assay
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[PMID: 9677265] |
| CCD-18Co | IC50 |
59.11 μg/mL
Compound: 7, phenolic acid C13:0
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Growth inhibition of human CCD-18Co cells after 2 days by SRB assay
Growth inhibition of human CCD-18Co cells after 2 days by SRB assay
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[PMID: 9677265] |
| HCT-15 | IC50 |
>50 μg/mL
Compound: 7, phenolic acid C13:0
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Growth inhibition of human HCT15 cells after 2 days by SRB assay
Growth inhibition of human HCT15 cells after 2 days by SRB assay
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[PMID: 9677265] |
| HT1197 | IC50 |
44.64 μg/mL
Compound: 7, phenolic acid C13:0
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Growth inhibition of human HT1197 cells after 2 days by SRB assay
Growth inhibition of human HT1197 cells after 2 days by SRB assay
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[PMID: 9677265] |
| MCF7 | IC50 |
22.67 μg/mL
Compound: 7, phenolic acid C13:0
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Growth inhibition of human MCF7 cells after 2 days by SRB assay
Growth inhibition of human MCF7 cells after 2 days by SRB assay
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[PMID: 9677265] |
| SK-OV-3 | IC50 |
20.4 μg/mL
Compound: 7, phenolic acid C13:0
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Growth inhibition of human SKOV3 cells after 2 days by SRB assay
Growth inhibition of human SKOV3 cells after 2 days by SRB assay
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[PMID: 9677265] |
Ginkgolic Acid (C13:0) (0-64 μg/mL; 0-24 h) can inhibit and kill S. mutans (MIC: 4 μg/mL; MBC: 8 μg/mL), and also inhibit its adhesion to saliva-coated hydroxyapatite, acid production, and biofilm formation[1].
Ginkgolic Acid (C13:0) (1-100 μM; 1.5 h) significantly inhibits the release of DNP-BSA-induced β-hexosaminidase in RBL-2H3 mast cells and reduces IgE/BSA-induced mast cell degranulation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 20261-38-5
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Appearance Solid
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Molecular Weight 320.47
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Formula C20H32O3
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Color White to off-white
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SMILES
O=C(O)C1=C(CCCCCCCCCCCCC)C=CC=C1O
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Synonyms
Ginkgolic acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic acid
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (312.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. He J, et al. Effects of ginkgoneolic acid on the growth, acidogenicity, adherence, and biofilm of Streptococcus mutans in vitro. Folia Microbiol (Praha). 2013 Mar;58(2):147-53. [Content Brief]
[2]. Guo JF, et al. Discovery of a natural PI3Kδ inhibitor through virtual screening and biological assay study. Biochem Biophys Res Commun. 2019 Jan 15;508(3):709-714. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1204 mL | 15.6021 mL | 31.2042 mL | 78.0104 mL |
| 5 mM | 0.6241 mL | 3.1204 mL | 6.2408 mL | 15.6021 mL | |
| 10 mM | 0.3120 mL | 1.5602 mL | 3.1204 mL | 7.8010 mL | |
| 15 mM | 0.2080 mL | 1.0401 mL | 2.0803 mL | 5.2007 mL | |
| 20 mM | 0.1560 mL | 0.7801 mL | 1.5602 mL | 3.9005 mL | |
| 25 mM | 0.1248 mL | 0.6241 mL | 1.2482 mL | 3.1204 mL | |
| 30 mM | 0.1040 mL | 0.5201 mL | 1.0401 mL | 2.6003 mL | |
| 40 mM | 0.0780 mL | 0.3901 mL | 0.7801 mL | 1.9503 mL | |
| 50 mM | 0.0624 mL | 0.3120 mL | 0.6241 mL | 1.5602 mL | |
| 60 mM | 0.0520 mL | 0.2600 mL | 0.5201 mL | 1.3002 mL | |
| 80 mM | 0.0390 mL | 0.1950 mL | 0.3901 mL | 0.9751 mL | |
| 100 mM | 0.0312 mL | 0.1560 mL | 0.3120 mL | 0.7801 mL |
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