PG-11047 tetrahydrochloride
Based on 1 Customer Validation
PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities.
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 206991-64-2
- Formula: C14H36Cl4N4
- Molecular Weight:402.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.25 μM
Compound: cis-14, CGC-11047
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Antitumor activity against human A549 cells
Antitumor activity against human A549 cells
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[PMID: 19534534] |
| DU-145 | IC50 |
0.25 μM
Compound: cis-14, CGC-11047
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Antitumor activity against human DU145 cells
Antitumor activity against human DU145 cells
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[PMID: 19534534] |
| HT-29 | IC50 |
0.25 μM
Compound: cis-14, CGC-11047
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Antitumor activity against human HT-29 cells
Antitumor activity against human HT-29 cells
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[PMID: 19534534] |
| MCF7 | IC50 |
9.25 μM
Compound: cis-14, CGC-11047
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Antitumor activity against human MCF7 cells
Antitumor activity against human MCF7 cells
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[PMID: 19534534] |
| PC-3 | IC50 |
0.25 μM
Compound: cis-14, CGC-11047
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Antitumor activity against human PC3 cells
Antitumor activity against human PC3 cells
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[PMID: 19534534] |
| U-251 | IC50 |
0.25 μM
Compound: cis-14, CGC-11047
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Antitumor activity against human U251MG cells
Antitumor activity against human U251MG cells
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[PMID: 19534534] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 206991-64-2
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Appearance Solid
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Molecular Weight 402.27
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Formula C14H36Cl4N4
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Color Off-white to light yellow
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SMILES
CCNCCCNC/C=C\CNCCCNCC.[H]Cl.[H]Cl.[H]Cl.[H]Cl
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Synonyms
CGC-11047 tetrahydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 100 mg/mL (248.59 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Wen-Lin Kuo, et al. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009 Dec 14;7:77. [Content Brief]
[2]. Murray Stewart T, et al. A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma. Cancer Chemother Pharmacol. 2021 Jan;87(1):135-144. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.4859 mL | 12.4295 mL | 24.8589 mL | 62.1473 mL |
| 5 mM | 0.4972 mL | 2.4859 mL | 4.9718 mL | 12.4295 mL | |
| 10 mM | 0.2486 mL | 1.2429 mL | 2.4859 mL | 6.2147 mL | |
| 15 mM | 0.1657 mL | 0.8286 mL | 1.6573 mL | 4.1432 mL | |
| 20 mM | 0.1243 mL | 0.6215 mL | 1.2429 mL | 3.1074 mL | |
| 25 mM | 0.0994 mL | 0.4972 mL | 0.9944 mL | 2.4859 mL | |
| 30 mM | 0.0829 mL | 0.4143 mL | 0.8286 mL | 2.0716 mL | |
| 40 mM | 0.0621 mL | 0.3107 mL | 0.6215 mL | 1.5537 mL | |
| 50 mM | 0.0497 mL | 0.2486 mL | 0.4972 mL | 1.2429 mL | |
| 60 mM | 0.0414 mL | 0.2072 mL | 0.4143 mL | 1.0358 mL | |
| 80 mM | 0.0311 mL | 0.1554 mL | 0.3107 mL | 0.7768 mL | |
| 100 mM | 0.0249 mL | 0.1243 mL | 0.2486 mL | 0.6215 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PG-11047 tetrahydrochloride Related Classifications
HY-16394 Related Classifications
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