2. Apoptosis
  3. Apoptosis
  4. Diselaginellin B

Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells.

For research use only. We do not sell to patients.

Diselaginellin B

Diselaginellin B Chemical Structure

CAS No. : 1835299-12-1

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Diselaginellin B Related Antibodies

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Description

Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells[1].

Cellular Effect
Cell Line Type Value Description References
SMMC-7721 IC50
9 μM
Compound: 2
Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29144743]
In Vitro

Diselaginellin B (2.5-10 μM) exhibits cytotoxic activity against SMMC-7721 cells, with an IC50 of 9.0 μM, and induces apoptosis in a concentration-dependent manner, by upregulating levels of DLD and inhibiting expressions of COX-1/2 and NNMT[1].
Diselaginellin B (0.5-2 μM) downregulates the TSPAN8 and MAGP2, inhibits the angiogenesis and reduces the cancer cells migration and invasion in SMMC-7721[1].
Diselaginellin B (2.5-5 μM) arrests the cells at G1 phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diselaginellin B Related Antibodies

Cell Invasion Assay[1]

Cell Line: SMMC-7721
Concentration: 0.5-2 μM
Incubation Time: 48 h
Result: Reduced the cancer cells migration and invasion in a dose-dependent manner.

Real Time qPCR[1]

Cell Line: SMMC-7721
Concentration: 8 μM
Incubation Time: 3 days
Result: Upregulated DLD, decreased expressions of COX-1/2, NNMT, TSPAN8 and MAGP2
Molecular Weight

1007.09

Formula

C68H46O9
CAS No.
SMILES

OC1=CC=C(/C(C2=C(C#CC3=CC=C(OCC4=CC=C(C5=CC=C(O)C=C5)C(/C(C6=CC=C(O)C=C6)=C(C=C7)/C=CC7=O)=C4C#CC8=CC=C(O)C=C8)C=C3)C(CO)=CC=C2C9=CC=C(O)C=C9)=C(C=C%10)\C=CC%10=O)C=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Diselaginellin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diselaginellin B1835299-12-1ApoptosisSMMC-7721HCCSelaginella PulvinataInhibitorinhibitorinhibit

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