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Art. -Nr.: HY-N12601

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Diselaginellin B

Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells.

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CAS. Nr.: 1835299-12-1
Formel: C₆₈H₄₆O₉
Molecular Weight:1007.09

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Diselaginellin B Chemical Structure

CAS. Nr.: 1835299-12-1

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
SMMC-7721	IC₅₀	9 μM Compound: 2	Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29144743]

In Vitro

Diselaginellin B (2.5-10 μM) exhibits cytotoxic activity against SMMC-7721 cells, with an IC₅₀ of 9.0 μM, and induces apoptosis in a concentration-dependent manner, by upregulating levels of DLD and inhibiting expressions of COX-1/2 and NNMT^[1].
Diselaginellin B (0.5-2 μM) downregulates the TSPAN8 and MAGP2, inhibits the angiogenesis and reduces the cancer cells migration and invasion in SMMC-7721^[1].
Diselaginellin B (2.5-5 μM) arrests the cells at G1 phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Invasion Assay^[1]

Cell Line:

SMMC-7721
Concentration:

0.5-2 μM
Incubation Time:

48 h
Result:

Reduced the cancer cells migration and invasion in a dose-dependent manner.

Real Time qPCR^[1]

Cell Line:

SMMC-7721
Concentration:

8 μM
Incubation Time:

3 days
Result:

Upregulated DLD, decreased expressions of COX-1/2, NNMT, TSPAN8 and MAGP2

Chemical Information

CAS. Nr. 1835299-12-1
Molecular Weight 1007.09
Formel C₆₈H₄₆O₉
SMILES

OC1=CC=C(/C(C2=C(C#CC3=CC=C(OCC4=CC=C(C5=CC=C(O)C=C5)C(/C(C6=CC=C(O)C=C6)=C(C=C7)/C=CC7=O)=C4C#CC8=CC=C(O)C=C8)C=C3)C(CO)=CC=C2C9=CC=C(O)C=C9)=C(C=C%10)\C=CC%10=O)C=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cao Y, et al., Diselaginellin B, an Unusual Dimeric Molecule from Selaginella pulvinata, Inhibited Metastasis and Induced Apoptosis of SMMC-7721 Human Hepatocellular Carcinoma Cells. J Nat Prod. 2017 Dec 22;80(12):3151-3158. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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