Diselaginellin B
Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells.
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- CAS No.: 1835299-12-1
- 화학식: C68H46O9
- 분자량:1007.09
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| SMMC-7721 | IC50 |
9 μM
Compound: 2
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Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29144743] |
In Vitro
Diselaginellin B (2.5-10 μM) exhibits cytotoxic activity against SMMC-7721 cells, with an IC50 of 9.0 μM, and induces apoptosis in a concentration-dependent manner, by upregulating levels of DLD and inhibiting expressions of COX-1/2 and NNMT[1].
Diselaginellin B (0.5-2 μM) downregulates the TSPAN8 and MAGP2, inhibits the angiogenesis and reduces the cancer cells migration and invasion in SMMC-7721[1].
Diselaginellin B (2.5-5 μM) arrests the cells at G1 phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SMMC-7721
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Concentration:0.5-2 μM
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Incubation Time:48 h
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Result:Reduced the cancer cells migration and invasion in a dose-dependent manner.
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Cell Line:SMMC-7721
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Concentration:8 μM
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Incubation Time:3 days
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Result:Upregulated DLD, decreased expressions of COX-1/2, NNMT, TSPAN8 and MAGP2
Chemical Information
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CAS No. 1835299-12-1
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분자량 1007.09
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화학식 C68H46O9
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SMILES
OC1=CC=C(/C(C2=C(C#CC3=CC=C(OCC4=CC=C(C5=CC=C(O)C=C5)C(/C(C6=CC=C(O)C=C6)=C(C=C7)/C=CC7=O)=C4C#CC8=CC=C(O)C=C8)C=C3)C(CO)=CC=C2C9=CC=C(O)C=C9)=C(C=C%10)\C=CC%10=O)C=C1
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Diselaginellin B Related Classifications
HY-N12601 Related Classifications
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