Diselaginellin B, an Unusual Dimeric Molecule from Selaginella pulvinata, Inhibited Metastasis and Induced Apoptosis of SMMC-7721 Human Hepatocellular Carcinoma Cells

  • J Nat Prod. 2017 Dec 22;80(12):3151-3158. doi: 10.1021/acs.jnatprod.7b00404.
Yuan Cao  1  2  3 ,  Ming Zhao  2 ,  Yue Zhu  2 ,  Zhen-Hua Zhu  2 ,  Lukas Oberer  4 ,  Jin-Ao Duan  2
Affiliations
  • 1. Department of Pharmacy, Affiliated Hospital of Nanjing University of Chinese Medicine , Nanjing 210036, People's Republic of China.
  • 2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine , Nanjing 210023, People's Republic of China.
  • 3. Department of Pharmacology, University of California, Irvine , Irvine, California 92697, United States.
  • 4. Novartis Institute of Biomedical Research (NIBR) , 4056 Basel, Switzerland.
PMID: 29144743 DOI: 10.1021/acs.jnatprod.7b00404
Abstract

Two new unusual dimeric selaginellins, diselaginellins A and B (1 and 2), along with two known derivatives, selaginellin (3) and selaginellin B (4), were isolated from Selaginella pulvinata. Their structures were elucidated by extensive NMR and high-resolution ESIMS data analysis. Compound 2 displayed apoptosis-inducing and antimetastatic activities against the human hepatocellular carcinoma cell line SMMC-7721. A microarray analysis revealed that genes related to metabolism, angiogenesis, and metastasis were altered by 2. The up- and down-regulation of the mRNA levels of related genes was confirmed by RT-qPCR. Metabolism modulation and metastasis inhibition might be the mechanisms of the antitumor properties of diselaginellin B (2).

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