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Cat. No.: HY-N1684

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20-Deoxyingenol 3-angelate

Name: 20-Deoxyingenol 3-angelate
Brand: MedChemExpress
SKU: HY-N1684
Price: 460.00 USD
Availability: InStock
Rating: 5 (1 reviews)

20-Deoxyingenol 3-angelate (DI3A) increases degranulation and interferon-gamma secretion of NK cells. 20-Deoxyingenol 3-angelate enhances NK cell tumoricidal activity.

For research use only. We do not sell to patients.

CAS No.: 75567-38-3

Formula: C₂₅H₃₄O₅

Molecular Weight:414.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

20-Deoxyingenol 3-angelate Chemical Structure

CAS No.: 75567-38-3

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Data Sheet (273 KB)

Handling Instructions (2659 KB)

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Bioz

Biological Activity

Description

20-Deoxyingenol 3-angelate (DI3A) increases degranulation and interferon-gamma secretion of NK cells. 20-Deoxyingenol 3-angelate enhances NK cell tumoricidal activity^[1].

Cellular Effect

Cell Line

Type Value Description References

HeLa IC₅₀
>10 μM
Compound: 12

Cytotoxicity against human HeLa cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay

Cytotoxicity against human HeLa cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay
[PMID: 34665635]

HepG2 IC₅₀
>10 μM
Compound: 12

Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay

Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay
[PMID: 34665635]

MT4 CC₅₀
>9.7 μM
Compound: 17

Cytotoxicity against human MT4 cells after 3 days by CytoTox-Glo assay

Cytotoxicity against human MT4 cells after 3 days by CytoTox-Glo assay
[PMID: 30031972]

PC-3 IC₅₀
>10 μM
Compound: 12

Cytotoxicity against human PC-3 cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay

Cytotoxicity against human PC-3 cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay
[PMID: 34665635]

SK-MEL-28 IC₅₀
>10 μM
Compound: 12

Cytotoxicity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay

Cytotoxicity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay
[PMID: 34665635]

Chemical Information

CAS No. 75567-38-3

Molecular Weight 414.53

Formula C₂₅H₃₄O₅

SMILES

O[C@@]12[C@]3(C=C([C@@H]2OC(/C(C)=C\C)=O)C)C([C@](C=C([C@H]1O)C)([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]3C)=O

Structure Classification

Terpenoids

Diterpenoids

Initial Source

Plants

Meliaceae

Aglaia elliptifolia

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. Zihang Xu, et al. A high-throughput assay for screening natural products that boost NK cell-mediated killing of cancer cells. Pharm Biol. 2020, 58, 1. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

20-Deoxyingenol 3-angelate Related Classifications

HY-N1684 Related Classifications

Disease Areas

Cancer

Natural Products

Plants Terpenoids

Meliaceae Diterpenoids

Aglaia elliptifolia

Cancer

Cancer Metabolism and Metastasis

Bioz

Powered by Bioz See more details on Bioz

Keywords

20-Deoxyingenol 3-angelate
75567-38-3
Others
Natural Products
Inhibitor
inhibitor
inhibit

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