Angiotensinogen (1-14), human TFA
Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides.
For research use only. We do not sell to patients.
- Formula: C83H122N24O19.xC2HF3O2
- Molecular Weight:1760.01 (free acid)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Angiotensinogen (AGT) is the only precursor of all angiotensin peptides. Human AGT has 485 amino acids, including a 33 amino-acid signal peptide. The 10 N-terminal amino acids are cleaved by renin to provide angiotensin I (AngI), which is the source for an array of active angiotensin peptides[1].
Angiotensinogen isolated from most species is cleaved by human renin. Synthetic peptides containing the N-terminal amino-acid sequence of angiotensinogen were renin substrates[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1760.01 (free acid)
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Formula C83H122N24O19.xC2HF3O2
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Sequence Shortening
DRVYIHPFHLVIHN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lu H, et al. Structure and functions of angiotensinogen. Hypertens Res. 2016 Jul;39(7):492-500. [Content Brief]
[2]. Burton J, et al. The amino-acid residues on the C-terminal side of the cleavage site of angiotensinogeninfluence the species specificity of reaction with renin. iochim Biophys Acta. 1988 Jan 4;952(1):8-12. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Angiotensinogen (1-14), human TFA Related Classifications
HY-P1486A Related Classifications
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