1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Angiotensinogen (1-14), human TFA

Angiotensinogen (1-14), human TFA 

Cat. No.: HY-P1486A
Handling Instructions

Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides.

For research use only. We do not sell to patients.

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Angiotensinogen (1-14), human TFA Chemical Structure

Angiotensinogen (1-14), human TFA Chemical Structure

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Description

Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides[1][2].

IC50 & Target[1][2]

Human Endogenous Metabolite

 

In Vitro

Angiotensinogen (AGT) is the only precursor of all angiotensin peptides. Human AGT has 485 amino acids, including a 33 amino-acid signal peptide. The 10 N-terminal amino acids are cleaved by renin to provide angiotensin I (AngI), which is the source for an array of active angiotensin peptides[1].
Angiotensinogen isolated from most species is cleaved by human renin. Synthetic peptides containing the N-terminal amino-acid sequence of angiotensinogen were renin substrates[2].

Molecular Weight

1874.06

Formula

C₈₅H₁₂₃N₂₄F₃O₂₁

Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn

Sequence Shortening

DRVYIHPFHLVIHN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Angiotensinogen (1-14), humanEndogenous MetabolitefragmentreninsubstrateangiotensinogenprecursorangiotensinpeptidesInhibitorinhibitorinhibit

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Angiotensinogen (1-14), human TFA
Cat. No.:
HY-P1486A
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