1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. ACY-1083

ACY-1083 

Cat. No.: HY-111791
Handling Instructions

ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.

For research use only. We do not sell to patients.

ACY-1083 Chemical Structure

ACY-1083 Chemical Structure

CAS No. : 1708113-43-2

Size Price Stock
5 mg USD 450 Get quote
10 mg USD 750 Get quote
50 mg USD 2250 Get quote
100 mg USD 3300 Get quote

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Description

ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].

IC50 & Target[1]

HDAC6

3 nM (IC50)

Molecular Weight

348.35

Formula

C₁₇H₁₈F₂N₄O₂

CAS No.

1708113-43-2

SMILES

FC(CC1)(F)CCC1(NC2=NC=C(C(NO)=O)C=N2)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (358.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8707 mL 14.3534 mL 28.7068 mL
5 mM 0.5741 mL 2.8707 mL 5.7414 mL
10 mM 0.2871 mL 1.4353 mL 2.8707 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
ACY-1083
Cat. No.:
HY-111791
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