1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. ACY-1083

ACY-1083 

Cat. No.: HY-111791
Handling Instructions

ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.

For research use only. We do not sell to patients.

ACY-1083 Chemical Structure

ACY-1083 Chemical Structure

CAS No. : 1708113-43-2

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Description

ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].

IC50 & Target[1]

HDAC6

3 nM (IC50)

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

348.35

Formula

C₁₇H₁₈F₂N₄O₂

CAS No.

1708113-43-2

SMILES

FC(CC1)(F)CCC1(NC2=NC=C(C(NO)=O)C=N2)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere

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ACY-1083
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HY-111791
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ACY-1083

Cat. No.: HY-111791