1708113-43-2
1708113-43-2
Chemical Structure
ACY-1083
- CAS No.: 1708113-43-2
- Formula:C17H18F2N4O2
- Molecular Weight:348.35
IUPAC Name: 2-((4,4-difluoro-1-phenylcyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide
InChIKey: MRWCVKLVSWYIFO-UHFFFAOYSA-N
SMILES: FC(CC1)(F)CCC1(NC2=NC=C(C(NO)=O)C=N2)C3=CC=CC=C3
Biological Activity: ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].
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ACY-1083 | 99.54% | ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy. | ||||||||||||||||||||
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References
Keywords
