SSE1806
SSE1806 is a derivative of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor with significant anticancer and antiproliferative activities. The GI50 of SSE1806 on cancer cell growth ranges from 1.29-21.15 μM. SSE1806 causes mitotic abnormalities and G2/M phase arrest, increases p53 expression, and inhibits colon cancer organoid growth. SSE1806 is able to overcome multidrug resistance in cell lines overexpressing MDR-1.
For research use only. We do not sell to patients.
- CAS No.: 3053861-26-7
- Formula: C21H18N2O5
- Molecular Weight:378.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BT-549 | GI50 |
7.05 μM
Compound: SSE1806
|
Antitumor activity against human BT-549 cells by MTS assay
Antitumor activity against human BT-549 cells by MTS assay
|
[PMID: 37849542] |
| CAL-51 | GI50 |
3.3 μM
Compound: SSE1806
|
Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay
Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay
|
[PMID: 37849542] |
| HCC1954 | GI50 |
21.15 μM
Compound: SSE1806
|
Antitumor activity against human HCC1954 cells by MTS assay
Antitumor activity against human HCC1954 cells by MTS assay
|
[PMID: 37849542] |
| HCT-116 | GI50 |
2.01 μM
Compound: SSE1806
|
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay
|
[PMID: 37849542] |
| K562 | GI50 |
17.74 μM
Compound: SSE1806
|
Antitumor activity against human K562 cells by MTS assay
Antitumor activity against human K562 cells by MTS assay
|
[PMID: 37849542] |
| KB 3-1 | GI50 |
1.29 μM
Compound: SSE1806
|
Antitumor activity against human KB-3-1 cells by MTS assay
Antitumor activity against human KB-3-1 cells by MTS assay
|
[PMID: 37849542] |
| KB 3-1 | GI50 |
1.29 μM
Compound: SSE1806
|
Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell proliferation
Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell proliferation
|
[PMID: 37849542] |
| KB-V1 | GI50 |
1.74 μM
Compound: SSE1806
|
Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell proliferation
Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell proliferation
|
[PMID: 37849542] |
| MCF7 | GI50 |
5.02 μM
Compound: SSE1806
|
Antitumor activity against human MCF7 cells by MTS assay
Antitumor activity against human MCF7 cells by MTS assay
|
[PMID: 37849542] |
| MOLM-13 | GI50 |
4.23 μM
Compound: SSE1806
|
Antitumor activity against human MOLM-13 cells by MTS assay
Antitumor activity against human MOLM-13 cells by MTS assay
|
[PMID: 37849542] |
| MV4-11 | GI50 |
9.45 μM
Compound: SSE1806
|
Antitumor activity against human MV4-11 cells by MTS assay
Antitumor activity against human MV4-11 cells by MTS assay
|
[PMID: 37849542] |
Chemical Information
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CAS No. 3053861-26-7
-
Molecular Weight 378.38
-
Formula C21H18N2O5
-
SMILES
O=C1CCCC2=C1C(C3=CC=CC([N+]([O-])=O)=C3)C4=CC(OCCO5)=C5C=C4N2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)