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Eurycomanone (Synonyms: Pasakbumin A)

Cat. No.: HY-N5012
Handling Instructions

Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

For research use only. We do not sell to patients.

Eurycomanone Chemical Structure

Eurycomanone Chemical Structure

CAS No. : 84633-29-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 162 In-stock
Estimated Time of Arrival: December 31
1 mg USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

In Vitro

Eurycomanone (EN) significantly increased testosterone production dose-dependently at 0.1, 1.0 and 10.0 μM, but the two lower doses when combined with 3-isobutyl-1-methylxanthine (IBMX), the phosphodiesterase inhibitor were not significantly higher than EN or IBMX alone, except at a higher concentration. The molecular docking studies indicated EN and IBMX were binding at different sites of the enzyme. EN has no reversal of inhibition by aminoglutethimide, ketoconazole or nifedipine at the respective steroid oogenesis enzyme. The quassinoid was also non-responsive to the inhibition of oestrogen receptor by tamoxifen, but displayed improved for mestane inhibition of aromatase in reducing oestrogen production. The molecular docking studies further supported that EN and formestane bound to aromatase with similar orientations and free energy binding values[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4486 mL 12.2429 mL 24.4858 mL
5 mM 0.4897 mL 2.4486 mL 4.8972 mL
10 mM 0.2449 mL 1.2243 mL 2.4486 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

408.40

Formula

C₂₀H₂₄O₉

CAS No.

84633-29-4

SMILES

O[[email protected]@]1([[email protected]]2O)[[email protected]@]34[[email protected]@]([[email protected]](OC4)(O)[[email protected]](O)C1=C)([H])[[email protected]]([[email protected]@](C(C)=CC5=O)([H])C[[email protected]@]3([H])OC2=O)([[email protected]@H]5O)C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Eurycomanone
Cat. No.:
HY-N5012
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Eurycomanone

Cat. No.: HY-N5012