2. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  3. PROTACs JAK
  4. SJ1008030 formic

SJ1008030 (compound 8) formic is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 formic inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 formic can be used for the research of leukemia.

For research use only. We do not sell to patients.

SJ1008030 formic Chemical Structure

SJ1008030 formic Chemical Structure

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Based on 1 publication(s) in Google Scholar

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SJ1008030 formic Related Antibodies

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Description

SJ1008030 (compound 8) formic is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 formic inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 formic can be used for the research of leukemia[1].

IC50 & Target[1]

JAK2

 

In Vitro

SJ1008030 (compound 8) formic (72 h) shows activity in CRLF2r cell lines (MHH–CALL-4), with an IC50 of 5.4 nM[1].
SJ1008030 (0-4.3 μM; 72 h) formic degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH–CALL-4 cells[1].
SJ1008030 (0-10 μM; 24h) formic dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating the inhibition of JAK-STAT signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SJ1008030 formic Related Antibodies
Molecular Weight

919.96

Formula

C43H45N13O9S
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(CC)(N1CC(N2C=C(C=N2)C3=C4C=CNC4=NC(NC5=CC=C(C=C5)C(NCCN6CCN(CC6)C7=CC=C8C(N(C9CCC(NC9=O)=O)C(C8=C7)=O)=O)=O)=N3)(CC#N)C1)=O.OC=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (135.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0870 mL 5.4350 mL 10.8700 mL
5 mM 0.2174 mL 1.0870 mL 2.1740 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.66%

COA (251 KB) HNMR (351 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0870 mL 5.4350 mL 10.8700 mL 27.1751 mL
5 mM 0.2174 mL 1.0870 mL 2.1740 mL 5.4350 mL
10 mM 0.1087 mL 0.5435 mL 1.0870 mL 2.7175 mL
15 mM 0.0725 mL 0.3623 mL 0.7247 mL 1.8117 mL
20 mM 0.0544 mL 0.2718 mL 0.5435 mL 1.3588 mL
25 mM 0.0435 mL 0.2174 mL 0.4348 mL 1.0870 mL
30 mM 0.0362 mL 0.1812 mL 0.3623 mL 0.9058 mL
40 mM 0.0272 mL 0.1359 mL 0.2718 mL 0.6794 mL
50 mM 0.0217 mL 0.1087 mL 0.2174 mL 0.5435 mL
60 mM 0.0181 mL 0.0906 mL 0.1812 mL 0.4529 mL
80 mM 0.0136 mL 0.0679 mL 0.1359 mL 0.3397 mL
100 mM 0.0109 mL 0.0544 mL 0.1087 mL 0.2718 mL
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SJ1008030 formic Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ1008030SJ 1008030SJ-1008030PROTACsJAKJanus kinaseantileukemiCRLF2r ALLMHH–CALL-4JAK-STAT signaling pathwaydegraderInhibitorinhibitorinhibit

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