2. PROTAC Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. PROTACs JAK
  4. SJ1008030

SJ1008030 (compound 8) is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 can be used for the research of leukemia.

For research use only. We do not sell to patients.

SJ1008030 Chemical Structure

SJ1008030 Chemical Structure

CAS No. : 2863634-96-0

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SJ1008030 Related Antibodies

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Description

SJ1008030 (compound 8) is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 can be used for the research of leukemia[1].

IC50 & Target

IC50: 32.09 nM (MHH-CALL-4), 33.41 nM (MHH-CALL4-GSPT1-WT), 33.55 nM (MHH-CALL-4-GSPT1-G575N) [1]
In Vitro

SJ1008030 (compound 8) (72 h) shows activity in CRLF2r cell lines (MHH–CALL-4), with an IC50 of 5.4 nM[1].
SJ1008030 (0-4.3 μM; 72 h) degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH–CALL-4 cells[1].
SJ1008030 (0-10 μM; 24h) dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating the inhibition of JAK-STAT signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SJ1008030 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: The CRLF2r cell lines MHH–CALL-4, KOPN49, MHH–CALL-2, KOP N75, NALM-6 and 697
Concentration: 0-3 μM
Incubation Time: 72 hours
Result: Showed best activity in MHH–CALL-4 cells with an EC50 value of 5.4 nM.

Western Blot Analysis[1]

Cell Line: MHH–CALL-4 cells
Concentration: 1 nM, 10 nM, 100 nM, 1 μM and 4.3 μM
Incubation Time: 72 hours
Result: Significantly degradated JAK2 in MHH–CALL-4 cells dose-dependently while showed weakly effect to JAK1, JAK3 and GSPT1.

Western Blot Analysis[1]

Cell Line: Xenograft SJBALL021415 bone marrow cells
Concentration: 1, 10, 100, 1000 and 1000 nM
Incubation Time: 24 hours
Result: Near-completely degradated JAK2 in a dose-dependent way while showed no effect on GSPT1.
Molecular Weight

873.94

Formula

C42H43N13O7S
CAS No.
SMILES

O=S(CC)(N1CC(N2C=C(C=N2)C3=C4C=CNC4=NC(NC5=CC=C(C=C5)C(NCCN6CCN(CC6)C7=CC=C8C(N(C9CCC(NC9=O)=O)C(C8=C7)=O)=O)=O)=N3)(CC#N)C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SJ1008030 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ10080302863634-96-0SJ 1008030SJ-1008030PROTACsJAKJanus kinaseantileukemiCRLF2r ALLMHH–CALL-4JAK-STAT signaling pathwaydegraderInhibitorinhibitorinhibit

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