SJ1008030 TFA
Based on 1 Customer Validation
SJ1008030 (compound 8) TFA is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 TFA inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 TFA can be used for the research of leukemia.
(Pink: JAK2 ligand (HY-15315); Blue: Cereblon ligand (HY-W834174); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.12%
- CAS No.: 2863634-97-1
- Formula: C44H44F3N13O9S
- Molecular Weight:987.96
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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JAK2 |
SJ1008030 (compound 8) (72 h) TFA shows activity in CRLF2r cell lines (MHH-CALL-4), with an IC50 of 5.4 nM[1]. SJ1008030 (0-4.3 μM; 72 h) TFA degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH–CALL-4 cells[1]. SJ1008030 (0-10 μM; 24h) TFA dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating the inhibition of JAK-STAT signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2863634-97-1
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Appearance Solid
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Molecular Weight 987.96
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Formula C44H44F3N13O9S
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Color Light yellow to yellow
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SMILES
O=S(CC)(N1CC(N2C=C(C=N2)C3=C4C=CNC4=NC(NC5=CC=C(C=C5)C(NCCN6CCN(CC6)C7=CC=C8C(N(C9CCC(NC9=O)=O)C(C8=C7)=O)=O)=O)=N3)(CC#N)C1)=O.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (126.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0122 mL | 5.0609 mL | 10.1219 mL | 25.3047 mL |
| 5 mM | 0.2024 mL | 1.0122 mL | 2.0244 mL | 5.0609 mL | |
| 10 mM | 0.1012 mL | 0.5061 mL | 1.0122 mL | 2.5305 mL | |
| 15 mM | 0.0675 mL | 0.3374 mL | 0.6748 mL | 1.6870 mL | |
| 20 mM | 0.0506 mL | 0.2530 mL | 0.5061 mL | 1.2652 mL | |
| 25 mM | 0.0405 mL | 0.2024 mL | 0.4049 mL | 1.0122 mL | |
| 30 mM | 0.0337 mL | 0.1687 mL | 0.3374 mL | 0.8435 mL | |
| 40 mM | 0.0253 mL | 0.1265 mL | 0.2530 mL | 0.6326 mL | |
| 50 mM | 0.0202 mL | 0.1012 mL | 0.2024 mL | 0.5061 mL | |
| 60 mM | 0.0169 mL | 0.0843 mL | 0.1687 mL | 0.4217 mL | |
| 80 mM | 0.0127 mL | 0.0633 mL | 0.1265 mL | 0.3163 mL | |
| 100 mM | 0.0101 mL | 0.0506 mL | 0.1012 mL | 0.2530 mL |
SJ1008030 TFA Related Classifications
HY-147330A Related Classifications
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