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Cat. No.: HY-N5122

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Vindolinine

Name: Vindolinine
Brand: MedChemExpress
SKU: HY-N5122
Price: 690.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Vindolinine is a natural alkaloide that can be found in Catharanthus roseus. Vindolinine has antitumor activity.

For research use only. We do not sell to patients.

Purity : 97.69%
CAS No.: 5980-02-9
Formula: C₂₁H₂₄N₂O₂
Molecular Weight:336.43

Storage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Vindolinine Chemical Structure

CAS No.: 5980-02-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Vindolinine is a natural alkaloide that can be found in Catharanthus roseus^[1]. Vindolinine has antitumor activity.

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	26.3 μM Compound: 7	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 20462230]
A549	IC₅₀	26.3 μmol Compound: 7	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 20462230]
HL-60	IC₅₀	6.8 μM Compound: 7	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 20462230]
HL-60	IC₅₀	6.8 μmol Compound: 7	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 20462230]
MCF7	IC₅₀	21.9 μM Compound: 7	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 20462230]
MCF7	IC₅₀	21.9 μmol Compound: 7	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 20462230]
SMMC-7721	IC₅₀	20.7 μM Compound: 7	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 20462230]
SMMC-7721	IC₅₀	20.7 μmol Compound: 7	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 20462230]
SW480	IC₅₀	15.2 μM Compound: 7	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 20462230]
SW480	IC₅₀	15.2 μmol Compound: 7	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 20462230]

Chemical Information

CAS No. 5980-02-9
Appearance Solid
Molecular Weight 336.43
Formula C₂₁H₂₄N₂O₂
Color White to off-white
SMILES

COC([C@H]1[C@@]23[C@]4(C5=CC=CC=C5N3)[C@]6([H])[C@](C1)(C=CCN6CC4)[C@H]2C)=O
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Protocols

All Animals and Diseases

Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Werner Kohl, et al. Alkaloide aus Catharanthus roseus-Zellkulturen. Z. Naturforsch. 86b, 1153-1162 (1981).

[2]. Feng T, Li Y, Wang YY, Cai XH, Liu YP, Luo XD. Cytotoxic indole alkaloids from Melodinus tenuicaudatus. J Nat Prod. 2010;73(6):1075-1079. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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