Verbascose

Cat. No.: HY-N9369: FAQs
Data Sheet Handling Instructions

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Verbascose, an alacto-oligosac-charides (GOS), has potent immunostimulatory activity. Verbascose acts as a potential natural immunomodulatory agent.

For research use only. We do not sell to patients.

Verbascose Chemical Structure

CAS No. : 546-62-3

Size	Stock
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
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Description

Verbascose, an alacto-oligosac-charides (GOS), has potent immunostimulatory activity. Verbascose acts as a potential natural immunomodulatory agent^[1].

In Vitro

Verbascose (25, 50, 100, 200, 400 μg/mL; 12, 24, 36, 48 hours) significantly increases the viability of RAW264.7 cells^[1].
Verbascose has notable activity of promoting peritoneal macrophages to devour neutral red in a dose-dependent manner and exhibits its maximum activity of cell phagocytosis at a concentration of 200 μg/mL^[1].
Verbascose induces significant increases of NO production. Verbascose can enhance the ability of devouring neutral red of peritoneal macrophages and promote the release of nitric oxide and immune reactive molecules such as interleukin (IL)-6, IL-1β, interferon (IFN)-α, and IFN-γ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Verbascose (30, 90, 120 mg/kg/day; sc; for 8 days) at a medium dose of 90 mg/kg body weight can significantly increase the index of spleen, activity of lysozyme in spleen and serum, hemolysin level in serum, and swelling rate of earlap in the delayed type of hypersensitivity (DTH) of immunosuppressed female Kunming mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

828.72

Formula

C₃₀H₅₂O₂₆

CAS No.

546-62-3

SMILES

OC[C@@H](O1)[C@@H](O)[C@H](O)[C@]1(CO)O[C@@H](O2)[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO[C@@H](O3)[C@H](O)[C@@H](O)[C@@H](O)[C@H]3CO[C@@H](O4)[C@H](O)[C@@H](O)[C@@H](O)[C@H]4CO[C@@H](O5)[C@H](O)[C@@H](O)[C@@H](O)[C@H]5CO

Structure Classification

Saccharides

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (301.67 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2067 mL	6.0334 mL	12.0668 mL
5 mM	0.2413 mL	1.2067 mL	2.4134 mL
10 mM	0.1207 mL	0.6033 mL	1.2067 mL

View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhuqing Dai, et al. Immunomodulatory activity in vitro and in vivo of verbascose from mung beans (Phaseolus aureus). J Agric Food Chem. 2014 Nov 5;62(44):10727-35. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.2067 mL	6.0334 mL	12.0668 mL	30.1670 mL
	5 mM	0.2413 mL	1.2067 mL	2.4134 mL	6.0334 mL
	10 mM	0.1207 mL	0.6033 mL	1.2067 mL	3.0167 mL
	15 mM	0.0804 mL	0.4022 mL	0.8045 mL	2.0111 mL
	20 mM	0.0603 mL	0.3017 mL	0.6033 mL	1.5084 mL
	25 mM	0.0483 mL	0.2413 mL	0.4827 mL	1.2067 mL
	30 mM	0.0402 mL	0.2011 mL	0.4022 mL	1.0056 mL
	40 mM	0.0302 mL	0.1508 mL	0.3017 mL	0.7542 mL
	50 mM	0.0241 mL	0.1207 mL	0.2413 mL	0.6033 mL
	60 mM	0.0201 mL	0.1006 mL	0.2011 mL	0.5028 mL
	80 mM	0.0151 mL	0.0754 mL	0.1508 mL	0.3771 mL
	100 mM	0.0121 mL	0.0603 mL	0.1207 mL	0.3017 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Verbascose546-62-3OthersGOSimmunostimulatoryNORAW264.7Inhibitorinhibitorinhibit

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