2,3-Dihydroxypropyl decanoate
Based on 1 Customer Validation
2,3-Dihydroxypropyl decanoate (1-Decanoyl-rac-glycerol) is a derivative of Decanoic acid (HY-W015309) and a non-ionic surfactant, with an IC50 > 100 μM against Shp2-PTP, VHR and HePTP. 2,3-Dihydroxypropyl decanoate is found in the roots of Angelica dahurica (Baizhi). 2,3-Dihydroxypropyl decanoate acts as a component of reverse micelle systems for the encapsulation of proteins and nucleic acids.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 2277-23-8
- Formula: C13H26O4
- Molecular Weight:246.34
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
2,3-Dihydroxypropyl decanoate (>100 μM) does not inhibit the activity of Shp2-PTP, VHR, or HePTP at concentrations up to 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2277-23-8
-
Appearance Solid
-
Molecular Weight 246.34
-
Formula C13H26O4
-
Color White to off-white
-
SMILES
CCCCCCCCCC(=O)OCC(CO)O
-
Synonyms
1-Decanoyl-rac-glycerol
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (405.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (268 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0594 mL | 20.2972 mL | 40.5943 mL | 101.4858 mL |
| 5 mM | 0.8119 mL | 4.0594 mL | 8.1189 mL | 20.2972 mL | |
| 10 mM | 0.4059 mL | 2.0297 mL | 4.0594 mL | 10.1486 mL | |
| 15 mM | 0.2706 mL | 1.3531 mL | 2.7063 mL | 6.7657 mL | |
| 20 mM | 0.2030 mL | 1.0149 mL | 2.0297 mL | 5.0743 mL | |
| 25 mM | 0.1624 mL | 0.8119 mL | 1.6238 mL | 4.0594 mL | |
| 30 mM | 0.1353 mL | 0.6766 mL | 1.3531 mL | 3.3829 mL | |
| 40 mM | 0.1015 mL | 0.5074 mL | 1.0149 mL | 2.5371 mL | |
| 50 mM | 0.0812 mL | 0.4059 mL | 0.8119 mL | 2.0297 mL | |
| 60 mM | 0.0677 mL | 0.3383 mL | 0.6766 mL | 1.6914 mL | |
| 80 mM | 0.0507 mL | 0.2537 mL | 0.5074 mL | 1.2686 mL | |
| 100 mM | 0.0406 mL | 0.2030 mL | 0.4059 mL | 1.0149 mL |
2,3-Dihydroxypropyl decanoate Related Classifications
HY-W099617 Related Classifications
Powered by Bioz