Retinoic acid  (Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA)

Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors^{[1][2][3][4][5][6]}.

Retinoic acid (GMP) time- and dose- dependently induces differentiation of EC cells and ES cells into specific cell types^[1].
Retinoic acid (GMP) induces partial differentiation of F9 embryonal carcinoma cells into endoderm cells^[2].
Retinoic acid (GMP) (100 nM; 2-8 d) promotes photoreceptor differentiation in early postnatal retinal cultures^[3].
Retinoic acid (GMP) (0.1 μM; 10-12 d) induces human SH-SY5Y neuroblastoma cells differentiation with long cell processes^[4].
Retinoic acid (GMP) (0-10 μM; 48 h) dose-dependently induces morphologic differentiation of LA-N-1 human neuroblastoma cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Retinoic acid (GMP) (0.3 μM; embryos are immersed in tank water containing retinoic acid) accelerates of rod differentiation is observed following 24 and 48 hours of application in zebrafish^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

300.44

C₂₀H₂₈O₂

302-79-4

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)=C(C)CCC1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rohwedel J, et al. Induction of cellular differentiation by retinoic acid in vitro. Cells Tissues Organs. 1999;165(3-4):190-202.  [Content Brief]

  [2]. Sherman MI, et al. Differentiation of early mouse embryonic and teratocarcinoma cells in vitro: plasminogen activator production. Cancer Res.  [Content Brief]

  [3]. Kelley MW, et al. Retinoic acid promotes differentiation of photoreceptors in vitro. Development. 1994 Aug;120(8):2091-102.  [Content Brief]

  [4]. Påhlman S, et al. Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation. Cell Differ. 1984 Jun;14(2):135-44.  [Content Brief]

  [5]. Sidell N. Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro. J Natl Cancer Inst. 1982 Apr;68(4):589-96.  [Content Brief]

  [6]. Hyatt GA, et al. Retinoic acid alters photoreceptor development in vivo. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13298-303.  [Content Brief]