2. JAK/STAT Signaling PI3K/Akt/mTOR
  3. mTOR Pim
  4. LGB321 monohydrochloride

LGB321 monohydrochloride is a potent, selective, orally active and ATP competitive inhibitor of all three PIM kinases. LGB321 monohydrochloride inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in a number of cell lines derived from diverse hematologic malignancies. LGB321 monohydrochloride can be used for the research of hematologic malignancies.

For research use only. We do not sell to patients.

LGB321 monohydrochloride Chemical Structure

LGB321 monohydrochloride Chemical Structure

CAS No. : 1469925-36-7

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LGB321 monohydrochloride Related Antibodies

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Description

LGB321 monohydrochloride is a potent, selective, orally active and ATP competitive inhibitor of all three PIM kinases. LGB321 monohydrochloride inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in a number of cell lines derived from diverse hematologic malignancies. LGB321 monohydrochloride can be used for the research of hematologic malignancies[1].

Molecular Weight

493.91

Formula

C23H23ClF3N5O2
CAS No.
SMILES

O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C(N4C[C@@H](N)[C@H](O)[C@@H](C)C4)C=CN=C3.[H]Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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LGB321 monohydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LGB321 monohydrochloride1469925-36-7mTORPimMammalian target of RapamycinPim kinasesATPcompetitivePIMBADhematologic malignanciesInhibitorinhibitorinhibit

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