LGB321
LGB321 is an inhibitor of PIM2-dependent multiple myeloma cell lines, effectively inhibiting proliferation and key signaling pathways such as mTOR-C1 and phosphorylation of BAD.
For research use only. We do not sell to patients.
- CAS No.: 1210417-75-6
- Formula: C23H22F3N5O2
- Molecular Weight:457.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EOL1 | GI50 |
<40 nM
Compound: 5c
|
Cytotoxicity against human EOL-1 cells after 72 hrs by Cell Titre-Glo assay
Cytotoxicity against human EOL-1 cells after 72 hrs by Cell Titre-Glo assay
|
[PMID: 24900629] |
| KMS-11 | EC50 |
0.017 μM
Compound: 1
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Antiproliferative activity against human KMS-11 cells expressing firefly luciferase assessed as reduction in cell viability incubated for 72 hrs by cell titer-glo assay
Antiproliferative activity against human KMS-11 cells expressing firefly luciferase assessed as reduction in cell viability incubated for 72 hrs by cell titer-glo assay
|
[PMID: 33258605] |
| KMS-11 | EC50 |
0.02 μM
Compound: 3
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Antiproliferative activity against luciferase expressing human KMS11 cells after 72 hrs by Cell-TiterGlo assay
Antiproliferative activity against luciferase expressing human KMS11 cells after 72 hrs by Cell-TiterGlo assay
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[PMID: 26505898] |
Chemical Information
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CAS No. 1210417-75-6
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Molecular Weight 457.45
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Formula C23H22F3N5O2
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SMILES
O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C(N4C[C@@H](N)[C@H](O)[C@@H](C)C4)C=CN=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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