BBR-BODIPY
Based on 1 Customer Validation
BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins.
For research use only. We do not sell to patients.
- Purity: 98.15%
- CAS No.: 2456476-47-2
- Formula: C47H48BClF2N6O5
- Molecular Weight:861.18
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
|
Bax |
Caspase-9 |
BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) has anti-proliferative activity[1].
BBR-BODIPY (2-16 μM; 5-60 mins; MCF7 cells) could be quickly taken up into MCF7 cells in 5 mins and the fluorescence intensity exhibits a time-dependent manner[1].
BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) accumulates in mitochondria and overlaps with Mito tracker red to display yellow fluorescence with a Pearsons co-localization coefficient of 0.72[1].
BBR-BODIPY (8 μM, 12 hours) induces apoptosis in MCF7 cells through a mitochondrial pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7 and MDA-MB-231 cells
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Concentration:1 , 2 , 4 , 8 , 16 and 32 μM
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Incubation Time:24 hours
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Result:Inhibited with IC50 values of 40.81 and 41.46 μM for MCF7 and MDA-MB-231 cells, respectively.
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Cell Line:MCF7 cells
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Concentration:8 μM
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Incubation Time:12 hours
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Result:The amounts of Bax and Cyto C released from mitochondria and cleaved Caspase 9 were up-regulated in MCF7 cells.
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Chemical Information
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CAS No. 2456476-47-2
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Appearance Solid
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Molecular Weight 861.18
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Formula C47H48BClF2N6O5
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Color Orange to red
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SMILES
[F-][B+3]1([N]2=C(C)C=C(C)C2=C(C3=C(C)C=C(C)[N-]31)C4=CC=C(C=C4)OCCCCCCN5N=NC(COC6=C(C=CC7=CC8=[N+](C=C76)CCC9=CC%10=C(OCO%10)C=C89)OC)=C5)[F-].[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 62.5 mg/mL (72.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1612 mL | 5.8060 mL | 11.6120 mL | 29.0299 mL |
| 5 mM | 0.2322 mL | 1.1612 mL | 2.3224 mL | 5.8060 mL | |
| 10 mM | 0.1161 mL | 0.5806 mL | 1.1612 mL | 2.9030 mL | |
| 15 mM | 0.0774 mL | 0.3871 mL | 0.7741 mL | 1.9353 mL | |
| 20 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.4515 mL | |
| 25 mM | 0.0464 mL | 0.2322 mL | 0.4645 mL | 1.1612 mL | |
| 30 mM | 0.0387 mL | 0.1935 mL | 0.3871 mL | 0.9677 mL | |
| 40 mM | 0.0290 mL | 0.1451 mL | 0.2903 mL | 0.7257 mL | |
| 50 mM | 0.0232 mL | 0.1161 mL | 0.2322 mL | 0.5806 mL | |
| 60 mM | 0.0194 mL | 0.0968 mL | 0.1935 mL | 0.4838 mL |
BBR-BODIPY Related Classifications
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