ADH4 Protein, Human
ADH4 Protein, an enzyme, is involved in the metabolism of alcohol and other toxic compounds. Dysregulation of ADH4 Protein has been linked to alcohol-induced liver damage and susceptibility to certain diseases. Targeting ADH4 Protein may offer potential therapeutic interventions by modulating alcohol metabolism, protecting against liver damage, and reducing disease risk. ADH4 Protein, Human is the recombinant human-derived ADH4 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
- Documentation
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Biological Activity
ADH4 Protein, an enzyme, is involved in the metabolism of alcohol and other toxic compounds. Dysregulation of ADH4 Protein has been linked to alcohol-induced liver damage and susceptibility to certain diseases. Targeting ADH4 Protein may offer potential therapeutic interventions by modulating alcohol metabolism, protecting against liver damage, and reducing disease risk. ADH4 Protein, Human is the recombinant human-derived ADH4 protein, expressed by E. coli , with tag free.
The ADH4 protein exhibits catalytic activity dependent on NAD, enabling the oxidation of either all-trans-retinol or 9-cis-retinol. Additionally, it has been observed to oxidize long chain omega-hydroxy fatty acids, including 20-HETE, resulting in the production of both the intermediate aldehyde, 20-oxoarachidonate, and the end product, a dicarboxylic acid known as (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Furthermore, ADH4 protein is involved in the reduction of benzoquinones.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P08319 (M1-F380)
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Gene ID127
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Molecular Construction
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N-term
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ADH4 (M1-F380)
Accession # P08319 -
C-term
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Protein Length
Full Length
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Synonyms
ADH4; All-trans-retinol dehydrogenase [NAD(+)] ADH4; Alcohol dehydrogenase 4; Alcohol dehydrogenase class II pi chain
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AA Sequence
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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