ADH4 Protein, Human
ADH4 Protein, an enzyme, is involved in the metabolism of alcohol and other toxic compounds. Dysregulation of ADH4 Protein has been linked to alcohol-induced liver damage and susceptibility to certain diseases. Targeting ADH4 Protein may offer potential therapeutic interventions by modulating alcohol metabolism, protecting against liver damage, and reducing disease risk. ADH4 Protein, Human is the recombinant human-derived ADH4 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
ADH4 Protein, an enzyme, is involved in the metabolism of alcohol and other toxic compounds. Dysregulation of ADH4 Protein has been linked to alcohol-induced liver damage and susceptibility to certain diseases. Targeting ADH4 Protein may offer potential therapeutic interventions by modulating alcohol metabolism, protecting against liver damage, and reducing disease risk. ADH4 Protein, Human is the recombinant human-derived ADH4 protein, expressed by E. coli , with tag free.
Background
The ADH4 protein exhibits catalytic activity dependent on NAD, enabling the oxidation of either all-trans-retinol or 9-cis-retinol. Additionally, it has been observed to oxidize long chain omega-hydroxy fatty acids, including 20-HETE, resulting in the production of both the intermediate aldehyde, 20-oxoarachidonate, and the end product, a dicarboxylic acid known as (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Furthermore, ADH4 protein is involved in the reduction of benzoquinones.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P08319 (M1-F380)
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Gene ID127
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Molecular Construction
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N-term
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ADH4 (M1-F380)
Accession # P08319 -
C-term
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Protein Length
Full Length
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Synonyms
ADH4; Epididymis Secretory Protein Li 4; Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide; Alcohol Dehydrogenase 4; ADH-2; Aldehyde Reductase; All-Trans-Retinol Dehydrogenase [NAD(+)] ADH4; HEL-S-4; Alcohol Dehydrogenase Class II Pi Chain; ADH2; Alcohol
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AA Sequence
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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