1. Epigenetics
  2. Epigenetic Reader Domain
  3. SNDX-5613

SNDX-5613 

Cat. No.: HY-136175
Handling Instructions

SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

SNDX-5613 Chemical Structure

SNDX-5613 Chemical Structure

CAS No. : 2169919-21-3

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Description

SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].

IC50 & Target

Menin-MLL[1]

In Vivo

SNDX-5613 shows in vivo plasma IC50 of 53 nM. SNDX-5613 treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts[1].

Molecular Weight

630.82

Formula

C₃₂H₄₇FN₆O₄S

CAS No.

2169919-21-3

SMILES

O=C(N(CC)C(C)C)C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(CCN(C[[email protected]]5CC[[email protected]](NS(=O)(CC)=O)CC5)CC4)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SNDX-5613SNDX5613SNDX 5613Epigenetic Reader DomainMeninMLLLeukemiaacutelymphoblasticALLmyeloidAMLInhibitorinhibitorinhibit

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SNDX-5613
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HY-136175
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