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  2. Epigenetic Reader Domain
  3. SNDX-5613

SNDX-5613 

Cat. No.: HY-136175 Purity: 99.62%
Handling Instructions

SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

SNDX-5613 Chemical Structure

SNDX-5613 Chemical Structure

CAS No. : 2169919-21-3

Size Price Stock Quantity
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].

IC50 & Target

Menin-MLL[1]

In Vivo

SNDX-5613 shows in vivo plasma IC50 of 53 nM. SNDX-5613 treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

630.82

Formula

C₃₂H₄₇FN₆O₄S

CAS No.

2169919-21-3

SMILES

O=C(N(CC)C(C)C)C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(CCN(C[[email protected]]5CC[[email protected]](NS(=O)(CC)=O)CC5)CC4)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (66.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5852 mL 7.9262 mL 15.8524 mL
5 mM 0.3170 mL 1.5852 mL 3.1705 mL
10 mM 0.1585 mL 0.7926 mL 1.5852 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 4.17 mg/mL (6.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.17 mg/mL (6.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 4.17 mg/mL (6.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.62%

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Keywords:

SNDX-5613SNDX5613SNDX 5613Epigenetic Reader DomainMeninMLLLeukemiaacutelymphoblasticALLmyeloidAMLInhibitorinhibitorinhibit

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Product Name:
SNDX-5613
Cat. No.:
HY-136175
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