2. Anti-infection
  3. Parasite Antibiotic
  4. Nemadectin

Nemadectin  (Synonyms: CL-287088; LL-F28249 α)

Cat. No.: HY-112542 Purity: 99.79%
COA Handling Instructions

Molarity Calculator

Nemadectin (CL-287088), an orally active broad-spectrum endectocide, is highly efficacious against natural infections of all the major canine gastrointestinal helminthes. Anthelmintic activity.

For research use only. We do not sell to patients.

Nemadectin Chemical Structure

Nemadectin Chemical Structure

CAS No. : 102130-84-7

Size Price Stock Quantity
1 mg USD 120 In-stock
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 960 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Nemadectin:

Nemadectin Related Antibodies

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nemadectin (CL-287088), an orally active broad-spectrum endectocide, is highly efficacious against natural infections of all the major canine gastrointestinal helminthes. Anthelmintic activity[1].

IC50 & Target

Mite

 

In Vivo

Nemadectin is highly effective at 0.6 mg/kg BW against natural infections of all major species of canine intestinal helminths, when administered as a single oral dose, either as a liquid or a tablet[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

612.79

Formula

C36H52O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C/C(C[C@H](/C=C/C=C1CO[C@]([H])([C@@H](C(C)=C[C@]2(C3=O)[H])O)[C@@]\12O)C)=C\C[C@@]4([H])O[C@]5(O[C@@H]([C@H]([C@H](C5)O)C)/C(C)=C/C(C)C)C[C@](O3)([H])C4
Structure Classification
Initial Source

Streptomyces microflavus neau3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (163.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6319 mL 8.1594 mL 16.3188 mL
5 mM 0.3264 mL 1.6319 mL 3.2638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

COA (262 KB) HNMR (308 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6319 mL 8.1594 mL 16.3188 mL 40.7970 mL
5 mM 0.3264 mL 1.6319 mL 3.2638 mL 8.1594 mL
10 mM 0.1632 mL 0.8159 mL 1.6319 mL 4.0797 mL
15 mM 0.1088 mL 0.5440 mL 1.0879 mL 2.7198 mL
20 mM 0.0816 mL 0.4080 mL 0.8159 mL 2.0399 mL
25 mM 0.0653 mL 0.3264 mL 0.6528 mL 1.6319 mL
30 mM 0.0544 mL 0.2720 mL 0.5440 mL 1.3599 mL
40 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0199 mL
50 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8159 mL
60 mM 0.0272 mL 0.1360 mL 0.2720 mL 0.6800 mL
80 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5100 mL
100 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.4080 mL
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Nemadectin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemadectin102130-84-7CL-287088 LL-F28249 αCL287088CL 287088ParasiteAntibioticinfectionanthelminticendectocidecanineInhibitorinhibitorinhibit

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