1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. Tephrosin

Tephrosin (Synonyms: Deguelinol I; Hydroxydeguelin)

Cat. No.: HY-N1166
Handling Instructions

Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors.

For research use only. We do not sell to patients.

Tephrosin Chemical Structure

Tephrosin Chemical Structure

CAS No. : 76-80-2

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Description

Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors[1].

In Vitro

Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) [1].

Molecular Weight

410.42

Formula

C₂₃H₂₂O₇

CAS No.

76-80-2

SMILES

O=C1[[email protected]]2(O)[[email protected]](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C=CC(C)(C)OC5=CC=C14

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TephrosinDeguelinol IHydroxydeguelinEGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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