1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Tephrosin

Tephrosin (Synonyms: Deguelinol I; Hydroxydeguelin)

Cat. No.: HY-N1166 Purity: ≥97.0%
Handling Instructions

Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors.

For research use only. We do not sell to patients.

Tephrosin Chemical Structure

Tephrosin Chemical Structure

CAS No. : 76-80-2

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1 mg USD 380 In-stock
Estimated Time of Arrival: December 31
5 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Tephrosin

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Description

Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors[1].

In Vitro

Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

410.42

Formula

C₂₃H₂₂O₇

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Tephrosin
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