2. MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR Epigenetics
  3. ERK Akt PI3K Epigenetic Reader Domain
  4. 6-O-Isobutyrylbritannilactone

6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models.

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6-O-Isobutyrylbritannilactone Chemical Structure

6-O-Isobutyrylbritannilactone Chemical Structure

CAS No. : 1259933-02-2

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6-O-Isobutyrylbritannilactone Related Antibodies

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Description

6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models[1].

In Vitro

6-O-Isobutyrylbritannilactone (5-100 μM; 48 h) shows cytotoxicity against B16F10 cells stimulated by IBMX (100 μM; 24 h)[1].
6-O-Isobutyrylbritannilactone (5-30 μM; 12 h) dose-dependently inhibits whitening-related mRNA levels in B16F10 cells stimulated by IBMX (100 μM; 48 h)[1].
6-O-Isobutyrylbritannilactone (20 μM; 1-9 h) time-dependently inhibits the phosphorylation of ERK, AKT, and CREB[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-O-Isobutyrylbritannilactone Related Antibodies

RT-PCR[1]

Cell Line: B16F10 cells
Concentration: 5 μM, 10 μM, 20 μM, 30 μM
Incubation Time: 12 hours; with 100 μM IBMX for 48 hours
Result: Inhibited whitening-related mRNA levels, and resulted in completely inhibited expressions of melanogenesis-related protein levels at 20 μM.

Western Blot Analysis[1]

Cell Line: 20 μM
Concentration: 5 μM, 10 μM, 20 μM, 30 μM
Incubation Time: 1 h, 3 h, 6 h, and 9 h
Result: Inhibited the phosphorylation of ERK, AKT, and CREB. Demonstrated the melanogenesis suppression induced by IBMX via inaction of multiple signaling pathways.

Cell Cytotoxicity Assay[1]

Cell Line: B16F10 cells
Concentration: 5 μM, 10 μM, 20 μM, 50 μM, and 100 μM
Incubation Time: 24 hours
Result: Inhibited B16F10 cells viability in a dose-dependent manner.
In Vivo

6-O-Isobutyrylbritannilactone (10-100 μM; 48 h) significantly reduces pigmentation compared to the untreated controls in zebrafish embryos[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish embryos[1]
Dosage: 10 μM, 50 μM, and 100 μM
Administration: Dipped in culture for 48 hours
Result: Reduced pigmentation by approximately 8%, 13%, and 16%.
Molecular Weight

336.42

Formula

C19H28O5
CAS No.
SMILES

CC(C)C(O[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])CC(C)=C1[C@@H](C)CCCO)=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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6-O-Isobutyrylbritannilactone Related Classifications

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Keywords:

6-O-Isobutyrylbritannilactone1259933-02-2ERKAktPI3KEpigenetic Reader DomainExtracellular signal regulated kinasesPKBProtein kinase BPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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