6-O-Isobutyrylbritannilactone
Based on 1 Customer Validation
6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models.
For research use only. We do not sell to patients.
- Purity: 98.34%
- CAS No.: 1259933-02-2
- Formula: C19H28O5
- Molecular Weight:336.42
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
6-O-Isobutyrylbritannilactone (5-100 μM; 48 h) shows cytotoxicity against B16F10 cells stimulated by IBMX (100 μM; 24 h)[1].
6-O-Isobutyrylbritannilactone (5-30 μM; 12 h) dose-dependently inhibits whitening-related mRNA levels in B16F10 cells stimulated by IBMX (100 μM; 48 h)[1].
6-O-Isobutyrylbritannilactone (20 μM; 1-9 h) time-dependently inhibits the phosphorylation of ERK, AKT, and CREB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:B16F10 cells
-
Concentration:5 μM, 10 μM, 20 μM, 30 μM
-
Incubation Time:12 hours; with 100 μM IBMX for 48 hours
-
Result:Inhibited whitening-related mRNA levels, and resulted in completely inhibited expressions of melanogenesis-related protein levels at 20 μM.
-
Cell Line:20 μM
-
Concentration:5 μM, 10 μM, 20 μM, 30 μM
-
Incubation Time:1 h, 3 h, 6 h, and 9 h
-
Result:Inhibited the phosphorylation of ERK, AKT, and CREB. Demonstrated the melanogenesis suppression induced by IBMX via inaction of multiple signaling pathways.
-
Cell Line:B16F10 cells
-
Concentration:5 μM, 10 μM, 20 μM, 50 μM, and 100 μM
-
Incubation Time:24 hours
-
Result:Inhibited B16F10 cells viability in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Zebrafish embryos[1]
-
Dosage:10 μM, 50 μM, and 100 μM
-
Administration:Dipped in culture for 48 hours
-
Result:Reduced pigmentation by approximately 8%, 13%, and 16%.
Chemical Information
-
CAS No. 1259933-02-2
-
Appearance Solid
-
Molecular Weight 336.42
-
Formula C19H28O5
-
Color White to off-white
-
SMILES
CC(C)C(O[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])CC(C)=C1[C@@H](C)CCCO)=O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-O-Isobutyrylbritannilactone Related Classifications
HY-N10802 Related Classifications
Powered by Bioz