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  4. VK-II-86

VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress.

For research use only. We do not sell to patients.

VK-II-86 Chemical Structure

VK-II-86 Chemical Structure

CAS No. : 955371-84-3

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VK-II-86 Related Antibodies

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Description

VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress[1].

In Vivo

VK-II-86 markedly reduces the number of non-sustained and sustained ventricular tachyarrhythmias in the hypokalaemic murine whole-heart model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

420.50

Formula

C25H28N2O4
CAS No.
SMILES

OC(CCOC1=CC=CC(N2)=C1C3=C2C=CC=C3)CNCCOC4=CC=CC=C4OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (237.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3781 mL 11.8906 mL 23.7812 mL
5 mM 0.4756 mL 2.3781 mL 4.7562 mL
View the Complete Stock Solution Preparation Table

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3781 mL 11.8906 mL 23.7812 mL 59.4530 mL
5 mM 0.4756 mL 2.3781 mL 4.7562 mL 11.8906 mL
10 mM 0.2378 mL 1.1891 mL 2.3781 mL 5.9453 mL
15 mM 0.1585 mL 0.7927 mL 1.5854 mL 3.9635 mL
20 mM 0.1189 mL 0.5945 mL 1.1891 mL 2.9727 mL
25 mM 0.0951 mL 0.4756 mL 0.9512 mL 2.3781 mL
30 mM 0.0793 mL 0.3964 mL 0.7927 mL 1.9818 mL
40 mM 0.0595 mL 0.2973 mL 0.5945 mL 1.4863 mL
50 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1891 mL
60 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9909 mL
80 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5945 mL
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VK-II-86 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VK-II-86955371-84-3OthersTachyarrhythmiashypokalaemiaventricular arrhythmiaInhibitorinhibitorinhibit

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