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  3. Fluorescent Dye Interleukin Related Reactive Oxygen Species (ROS) NF-κB JNK Keap1-Nrf2 SOD
  4. Carminic acid

Carminic acid is a widely used and orally active natural red pigment that can be used in industries such as food, cosmetics, and pharmaceuticals. In addition, carminic acid has anti-inflammatory and antioxidant activities.

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Carminic acid

Carminic acid Chemical Structure

CAS No. : 1260-17-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Carminic acid:

Carminic acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Carminic acid is a widely used and orally active natural red pigment that can be used in industries such as food, cosmetics, and pharmaceuticals. In addition, carminic acid has anti-inflammatory and antioxidant activities[1][2][3][4].

IC50 & Target[1]

IL-1β

 

IL-6

 

IL-4

 

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
3730 μM
Compound: Carminic acid
Compound was evaluated for the inhibition of cell proliferation of human cervix epithelioid carcinoma, HeLa (ATCC CCL2).
Compound was evaluated for the inhibition of cell proliferation of human cervix epithelioid carcinoma, HeLa (ATCC CCL2).
10.1016/0960-894X(96)00418-0
HepG2 IC50
1770 μM
Compound: Carminic acid
Compound was evaluated for the inhibition of cell proliferation of human hepatocellular carcinoma, HepG2 (ATCC HB8065).
Compound was evaluated for the inhibition of cell proliferation of human hepatocellular carcinoma, HepG2 (ATCC HB8065).
10.1016/0960-894X(96)00418-0
In Vitro

Carminic acid (10-20 μM; 24 h) can reduce the levels of inflammatory factors, ROS, MDA, and H2O2 and increase the activity of SOD in Fructose (HY-N0395)-treated TCMK-1 and HK2 cells. The mechanism involves the inhibition of NF-κB and JNK and the activation of Nrf-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carminic acid Related Antibodies

Real Time qPCR[1]

Cell Line: TCMK-1 and HK2 cells treated Fructose (HY-N0395)
Concentration: 10 and 20 μM
Incubation Time: 24 h
Result: Markedly reduced the expression of IL-1β, IL-6, IL-4, IL-18, TNF-α, TGF-β1, MCP-1, TIMP-1, MIP-1α and CXCL1.
In Vivo

Carminic acid (0.75-1.5 g/kg; dietary administration; 16 weeks) has an improving effect in a mouse model of kidney injury[1].
Carminic acid (0.1-100 mM) has a deterrent effect on ant feeding[2].
Carminic acid (500-3000 mg/kg; oral gavage) can cause hyperactivity-like behaviors in rats at high doses (1500 and 3000 mg/kg), while the low dose (500 mg/kg) has no negative effects on the locomotor activity and anxiety behaviors of rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice aged 6-7 weeks old (18-20 g) treated Fructose (HY-N0395)[1]
Dosage: 0.75 and 1.5 g/kg/day
Administration: Dietary administration; 16 weeks
Result: Alleviated metabolic disorders.
Reduced body weight, blood glucose, blood lipid and insulin levels.
Improved glucose tolerance and insulin resistance.
Relieved renal dysfunction, mitigated glomerular hypertrophy and renal fibrosis.
Inhibited renal inflammation and oxidative stress, and enhanced the activation level of AMPKα.
Molecular Weight

492.39

Formula

C22H20O13
CAS No.
Appearance

Solid

Color

Brown to red

SMILES

O=C1C2=C(O)C([C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=C(O)C(O)=C2C(C4=CC(O)=C(C(O)=O)C(C)=C41)=O
Structure Classification
Initial Source

cochineal insects (Dactylopius species)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (236.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0309 mL 10.1546 mL 20.3091 mL
5 mM 0.4062 mL 2.0309 mL 4.0618 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.19%

SDS (394 KB)

COA (251 KB) HNMR (293 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0309 mL 10.1546 mL 20.3091 mL 50.7728 mL
5 mM 0.4062 mL 2.0309 mL 4.0618 mL 10.1546 mL
10 mM 0.2031 mL 1.0155 mL 2.0309 mL 5.0773 mL
15 mM 0.1354 mL 0.6770 mL 1.3539 mL 3.3849 mL
20 mM 0.1015 mL 0.5077 mL 1.0155 mL 2.5386 mL
25 mM 0.0812 mL 0.4062 mL 0.8124 mL 2.0309 mL
30 mM 0.0677 mL 0.3385 mL 0.6770 mL 1.6924 mL
40 mM 0.0508 mL 0.2539 mL 0.5077 mL 1.2693 mL
50 mM 0.0406 mL 0.2031 mL 0.4062 mL 1.0155 mL
60 mM 0.0338 mL 0.1692 mL 0.3385 mL 0.8462 mL
80 mM 0.0254 mL 0.1269 mL 0.2539 mL 0.6347 mL
100 mM 0.0203 mL 0.1015 mL 0.2031 mL 0.5077 mL
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Carminic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carminic acid1260-17-9Fluorescent DyeInterleukin RelatedReactive Oxygen Species (ROS)NF-κBJNKKeap1-Nrf2SODILNuclear factor-κBNuclear factor-kappaBc-Jun N-terminal kinaseSuperoxide Dismutasered colorantcoccid dyeTCMK-1 cellsHK2 cellskidney injury modelInhibitorinhibitorinhibit

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