N-Methyltyramine hydrochloride
Based on 1 Customer Validation
N-Methyltyramine hydrochloride is an orally active α2-adrenoreceptor antagonist with an IC50 value of 5.53 μM against rat targets. N-Methyltyramine hydrochloride blocks α2-adrenoreceptors, while inhibiting lipolysis, hyperactivity responses and small intestinal peristalsis in mice. N-Methyltyramine hydrochloride promotes gastrin release and pancreatic juice secretion, upregulates appetite, blood pressure, myocardial contraction frequency and contraction intensity, and increases renal blood flow, renal vascular resistance and mean peripheral arterial resistance. N-Methyltyramine hydrochloride relaxes mouse small intestinal smooth muscle and undergoes biotransformation in vivo to produce adrenaline. N-Methyltyramine hydrochloride can be used in studies related to gastrointestinal diseases.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 13062-76-5
- Formula: C9H14ClNO
- Molecular Weight:187.67
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
GPCR/G Protein Compound Library
HY-L006
-
Immunology/Inflammation Compound Library
HY-L007
-
Neuronal Signaling Compound Library
HY-L013
-
Natural Product Library
HY-L021
-
Phenols Library
HY-L057
-
Neurotransmitter Receptor Compound Library
HY-L062
-
Alkaloids Library
HY-L071
-
Anti-Obesity Compound Library
HY-L087
-
Antidepressant Compound Library
HY-L108
-
Plant-Sourced Natural Product Library
HY-L115
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Activators Library
HY-L159
-
Anti-Drug-Resistant Compound Library
HY-L169
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
RO5 Drug-like Natural Product Library
HY-L200
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Lactylation Compound Library
HY-L249
-
Mass Spectrometry Natural Product Library
HY-L262
All Adrenergic Receptor Isoforms
More
Biological Activity
|
α2-adrenergic receptor 5.53 μM (IC50) |
N-Methyltyramine hydrochloride mildly inhibits lipolysis in isolated rat and human adipocytes in vitro[1].
N-Methyltyramine hydrochloride inhibits the binding of [3H]-para-amino Clonidine (HY-12721) to α2-adrenergic receptors in crude synaptosomal membranes from rat brain, with an IC50 of 5.53 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
N-Methyltyramine (infused into stomach) hydrochloride dose-dependently stimulates pancreatic secretion in rats when infused into the stomach, with beer-derived NMT capable of driving greater than 50% secretion[1].
N-Methyltyramine hydrochloride administered intravenously at 0.04 mg/kg/min increases renal hemodynamic parameters and mean arterial pressure in dogs, while a 0.25 mg/kg i.v. bolus markedly elevates peripheral resistance[1].
Radio-labeled N-Methyltyramine (i.v.; single dose) hydrochloride distributes rapidly to all organs (with highest levels in liver and kidneys) and is rapidly excreted and metabolized in rabbits and mice following intravenous administration[1].
N-methyltyramine (20-100 mg/kg; i.p.; single dose) hydrochloride acts as an α2-adrenoceptor antagonist, dose-dependently inhibiting scopolamine (HY-N0296)-induced hypermotility in male ddY mice[2].
N-Methyltyramine (3-30 mg/kg; p.o.; single dose) hydrochloride dose-dependently inhibits mouse small intestinal propulsive function, with significant effects observed at 3 mg/kg, 9 mg/kg, and 30 mg/kg via oral administration[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 13062-76-5
-
Appearance Solid
-
Molecular Weight 187.67
-
Formula C9H14ClNO
-
Color White to off-white
-
SMILES
CNCCC1=CC=C(O)C=C1.Cl
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (532.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (133.21 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.32 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.32 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Stohs SJ. A Review of the Receptor Binding and Pharmacological Effects of N-methyltyramine. Phytotherapy Research. 2014;29(1):14-16. [Content Brief]
[3]. Ni J, et al. Effect of N-methyltyramine on the regulation of adrenergic receptors via enzymatic epinephrine synthesis for the treatment of gastrointestinal disorders. Biomedicine & Pharmacotherapy. 2019;111:1393-1398. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.3285 mL | 26.6425 mL | 53.2850 mL | 133.2126 mL |
| 5 mM | 1.0657 mL | 5.3285 mL | 10.6570 mL | 26.6425 mL | |
| 10 mM | 0.5329 mL | 2.6643 mL | 5.3285 mL | 13.3213 mL | |
| 15 mM | 0.3552 mL | 1.7762 mL | 3.5523 mL | 8.8808 mL | |
| 20 mM | 0.2664 mL | 1.3321 mL | 2.6643 mL | 6.6606 mL | |
| 25 mM | 0.2131 mL | 1.0657 mL | 2.1314 mL | 5.3285 mL | |
| 30 mM | 0.1776 mL | 0.8881 mL | 1.7762 mL | 4.4404 mL | |
| 40 mM | 0.1332 mL | 0.6661 mL | 1.3321 mL | 3.3303 mL | |
| 50 mM | 0.1066 mL | 0.5329 mL | 1.0657 mL | 2.6643 mL | |
| 60 mM | 0.0888 mL | 0.4440 mL | 0.8881 mL | 2.2202 mL | |
| 80 mM | 0.0666 mL | 0.3330 mL | 0.6661 mL | 1.6652 mL | |
| 100 mM | 0.0533 mL | 0.2664 mL | 0.5329 mL | 1.3321 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Methyltyramine hydrochloride Related Classifications
HY-W153159 Related Classifications
Powered by Bioz