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Cat. No.: HY-N8272

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Neocyclomorusin

Neocyclomorusin (compound 6) is a flavonoid. Neocyclomorusin can be isolated from Erythrina sigmoidea. Neocyclomorusin inhibits the CCRF-CEM cell line with an IC50 value of 59.02 μM.

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CAS No.: 62596-35-4
Formula: C₂₅H₂₄O₇
Molecular Weight:436.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Neocyclomorusin Chemical Structure

CAS No.: 62596-35-4

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Neocyclomorusin (compound 6) is a flavonoid. Neocyclomorusin can be isolated from Erythrina sigmoidea. Neocyclomorusin inhibits the CCRF-CEM cell line with an IC50 value of 59.02 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	146.1 μM Compound: 7	Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay	[PMID: 21511472]
RAW264.7	IC₅₀	6.3 μg/mL Compound: 5	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess assay	[PMID: 27908762]

Chemical Information

CAS No. 62596-35-4
Molecular Weight 436.45
Formula C₂₅H₂₄O₇
SMILES

O=C1C(C(OC(C(C(O2)=C3)=CC=C3O)=C1CC2C(C)(O)C)=C(C=CC4(C)C)C(O4)=C5)=C5O
Structure Classification
- Flavonoids
- Other Flavonoids
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Victor Kuete, et al. Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi-factorial drug resistant cancer cells. Investigational New Drugs. 2014, 32.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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