Anastrozole-d12
Based on 1 Customer Validation
Anastrozole-d12 is the deuterium labeled Anastrozole. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.74%
- CAS 番号: 120512-32-5
- 分子式: C17H7D12N5
- 分子量:305.44
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-113254S1
13,14-Dihydro-15-keto-PGE2-d9Stable Isotope -
HY-41417S
Octanoic acid-d15Stable Isotope -
HY-W587861
5β-DihydroprogesteroneTocolytic Agent -
HY-W011873S1
Palmitoleic acid-d13Stable Isotope -
HY-163376
17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amideProstaglandin Analog -
HY-14519S
Methotrexate-d3Stable Isotope -
HY-41417S3
Octanoic acid-13CStable Isotope -
HY-113246
15-keto-Prostaglandin F2aPGF2α Metabolite -
HY-B0279S
Ramipril-d5Stable Isotope -
HY-121779
o,p'-DDE -
HY-41417S1
Octanoic acid-d3Stable Isotope -
HY-124920
MethiocarbInsecticide
生物活性
製品説明
IC50 & Target
|
Aromatase |
体外実験
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
-
CAS 番号 120512-32-5
-
非標識Cas 120511-73-1
-
性状 Solid
-
分子量 305.44
-
分子式 C17H7D12N5
-
Color White to off-white
-
SMILES
N#CC(C([2H])([2H])[2H])(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C#N)=CC(CN2C=NC=N2)=C1)C([2H])([2H])[2H]
-
別名
ZD1033-d12
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
-
データシート (292 KB)
-
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Dukes M, et al. The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent, selective aromatase inhibitor. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anastrozole-d12 関連分類
HY-14274S 関連分類
Powered by Bioz