UDP-Galactose
Based on 5 publication(s) in Google Scholar
UDP-Galactose is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose is the natural agonist of the P2Y14 receptor coupled to Gi proteins in the immune system (IC50 = 0.67 μM, hP2Y14). UDP-Galactose can be used to study cell signal transduction and substance metabolism.
For research use only. We do not sell to patients.
- CAS No.: 2956-16-3
- Formula: C15H24N2O17P2
- Molecular Weight:566.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) UDP-Galactose
MoreAll Endogenous Metabolite Isoforms
MoreAll P2Y Receptor Isoforms
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Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
P2Y14 Receptor 0.67 μM (EC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| COS-7 | EC50 |
0.67 μM
Compound: 2
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Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis
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[PMID: 17407275] |
| COS-7 | EC50 |
0.67 μM
Compound: 7
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Agonist activity at human P2Y14 receptor expressed in human COS7 cells
Agonist activity at human P2Y14 receptor expressed in human COS7 cells
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[PMID: 19502066] |
In Vitro
UDP-Galactose (2 mM) restores UDP-galactose transport in the endoplasmic reticulum of GalT-1/UGT-CHOlec8 cells[2].
UDP-galactose is transported via the endoplasmic reticulum to support GalCer synthesis in GalT-1/UGT-CHOlec8 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2956-16-3
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Molecular Weight 566.30
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Formula C15H24N2O17P2
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SMILES
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)(O)=O)(O)=O)O2)NC1=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Mol Plant
2025 Dec 13:S1674-2052(25)00435-6. PMID: 41392480 -
Cell Rep
Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG. [Abstract]2025 Nov 18;44(12):116577. PMID: 41259203 -
J Exp Bot
Diel carbon buffering by floridoside enables source-sink resilience in the intertidal red alga Pyropia haitanensis. [Abstract]2026 Apr 17:erag189. PMID: 41999048 -
J Biotechnol
Rational design of a bifunctional glycosyltransferase for enhanced substrate promiscuity and thermostability. [Abstract]2025 Dec 19:410:285-297. PMID: 41422993 -
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1].
Ko H, et al. Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. J Med Chem. 2007 May 3;50(9):2030-9.
[Content Brief]
[2]. Sprong H, et al. Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. Mol Biol Cell. 2003;14(8):3482-3493. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UDP-Galactose Related Classifications
HY-150524 Related Classifications
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