Oryzalin

Name: Oryzalin
Brand: MedChemExpress
SKU: HY-147092
Rating: 4.5 (1 reviews)

Cat. No.: HY-147092 Purity: 99.62%: Data Sheet
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Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling.

For research use only. We do not sell to patients.

CAS No. : 19044-88-3

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Oryzalin:

Oryzalin (Standard) Get quote

1 Publications Citing Use of MCE Oryzalin

•Nat Commun. 2025 Jul 18;16(1):6621. [Abstract]

Cell Imaging/Staining

: Oryzalin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 18;16(1):6621. [Abstract]; Oryzalin (10 μM) and latrunculin B (10 μM) were employed to disrupt microtubule and microfilament structures, respectively.

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-8	IC₅₀	800 nM Compound: 2	Antimicrobial activity against Cryptosporidium parvum infected in HCT8 cells assessed as parasite count after 72 to 120 hrs Antimicrobial activity against Cryptosporidium parvum infected in HCT8 cells assessed as parasite count after 72 to 120 hrs	[PMID: 21889338]
HFF	IC₅₀	0.25 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.26 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.4 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.5 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.6 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	14.7 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	16 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	2.2 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	2.3 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	25.3 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	27.7 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	5.5 μM Compound: 10	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay	[PMID: 20145086]
J774	IC₅₀	44 μM Compound: 2 (Oryzalin)	In vitro cytotoxicity against mouse J774 macrophages. In vitro cytotoxicity against mouse J774 macrophages.	[PMID: 15027874]
PC-3	IC₅₀	56 μM Compound: 2 (Oryzalin)	In vitro cytotoxicity against mouse PC3 prostate cancer cell line. In vitro cytotoxicity against mouse PC3 prostate cancer cell line.	[PMID: 15027874]

In Vitro

Oryzalin (0.1 μM; 5 min) inhibits anaphase chromosome migration, depolymerizes microtubules, and prevents the polymerization of new microtubules at all stages of the mitotic cycle in the endosperm cells of Haemanthus katherinae Bak^[1].
Oryzalin (5-30 μM; in agar solution for 20-30 days) can double the chromosomes in isolated haploid apple stem segments with high survival rate and efficiency^[2].
Oryzalin (6-500 μM; 1 h) has high hemolytic activity in human red blood cells, with a hemolysis rate of approximately 20% at 100 μM^[2].
Oryzalin (6-50 μM; 48 h) has antileishmanial activity in THP-1 cells infected with L. infantum, with an IC₅₀ of 24.2 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

346.36

Formula

C₁₂H₁₈N₄O₆S

CAS No.

19044-88-3

Appearance

Solid

Color

Orange to red

SMILES

O=S(C1=CC([N+]([O-])=O)=C(N(CCC)CCC)C([N+]([O-])=O)=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 233.33 mg/mL (673.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8872 mL	14.4358 mL	28.8717 mL
5 mM	0.5774 mL	2.8872 mL	5.7743 mL
10 mM	0.2887 mL	1.4436 mL	2.8872 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.62%

Select Batch:

Data Sheet (277 KB) SDS (623 KB)

COA (253 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Morejohn LC, et al. Oryzalin, a dinitroaniline herbicide, binds to plant tubulin and inhibits microtubule polymerization in vitro. Planta. 1987 Oct;172(2):252-64. [Content Brief]

[2]. Bouvier L, et al. Oryzalin as an efficient agent for chromosome doubling of haploid apple shoots in vitro. Plant Breeding, 1994, 113(4): 343-346.

[3]. Lopes RM, et al. Formulation of oryzalin (ORZ) liposomes: in vitro studies and in vivo fate. Eur J Pharm Biopharm. 2012 Oct;82(2):281-90. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8872 mL	14.4358 mL	28.8717 mL	72.1792 mL
	5 mM	0.5774 mL	2.8872 mL	5.7743 mL	14.4358 mL
	10 mM	0.2887 mL	1.4436 mL	2.8872 mL	7.2179 mL
	15 mM	0.1925 mL	0.9624 mL	1.9248 mL	4.8119 mL
	20 mM	0.1444 mL	0.7218 mL	1.4436 mL	3.6090 mL
	25 mM	0.1155 mL	0.5774 mL	1.1549 mL	2.8872 mL
	30 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4060 mL
	40 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8045 mL
	50 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4436 mL
	60 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2030 mL
	80 mM	0.0361 mL	0.1804 mL	0.3609 mL	0.9022 mL
	100 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7218 mL

Oryzalin Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oryzalin19044-88-3Microtubule/TubulinEnvironmental PollutantsHerbicideEnvironmental Contaminantsplantmicrotubulemitotic cycleherbicideendosperm cells human red blood cells THP-1 cellsInhibitorinhibitorinhibit

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Oryzalin

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1 Publications Citing Use of MCE Oryzalin

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