country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-161080

Copy Link Print Information

4'-Ethynyl-2'-deoxycytidine

4'-Ethynyl-2'-deoxycytidine is an anticancer nucleoside. 4'-Ethynyl-2'-deoxycytidine can used in study acute lymphoblastic leukemia and diffuse large B-cell lymphoma.

For research use only. We do not sell to patients.

CAS No.: 232588-95-3
Formula: C₁₁H₁₃N₃O₄
Molecular Weight:251.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

4'-Ethynyl-2'-deoxycytidine Chemical Structure

CAS No.: 232588-95-3

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

4'-Ethynyl-2'-deoxycytidine is an anticancer nucleoside. 4'-Ethynyl-2'-deoxycytidine can used in study acute lymphoblastic leukemia and diffuse large B-cell lymphoma^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	0.00096 μM Compound: 58	Tested in vitro against HIV-1 104pre from HeLa-CD4-LT4-beta gal-cells using MAGI assay Tested in vitro against HIV-1 104pre from HeLa-CD4-LT4-beta gal-cells using MAGI assay	[PMID: 11087576]
HeLa	EC₅₀	0.96 nM Compound: 58	Tested in vitro against HIV-1 104pre from HeLa-CD4-LT4-beta gal-cells using MAGI assay Tested in vitro against HIV-1 104pre from HeLa-CD4-LT4-beta gal-cells using MAGI assay	[PMID: 11087576]
KB	IC₅₀	>350 μM Compound: 21	Cytotoxicity against KB cells. Cytotoxicity against KB cells.	[PMID: 10425099]
L1210	IC₅₀	0.8 μM Compound: 21	Cytotoxicity against L1210 cells. Cytotoxicity against L1210 cells.	[PMID: 10425099]
MT4	CC₅₀	0.92 μM Compound: 58	Tested in vitro against MT-4 cells using MTT assay Tested in vitro against MT-4 cells using MTT assay	[PMID: 11087576]
MT4	EC₅₀	0.0048 μM Compound: 58	Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assay Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assay	[PMID: 11087576]
MT4	CC₅₀	2.2 μM Compound: 44	Cytotoxicity against human MT4 cells after 4 days by MTT assay Cytotoxicity against human MT4 cells after 4 days by MTT assay	[PMID: 23795238]
MT4	EC₅₀	0.0048 μM Compound: 44	Antiviral activity against HIV-1 infected in human MT-4 cells assessed as inhibition of viral-induced cytopathogenicity after 4 days by MTT assay Antiviral activity against HIV-1 infected in human MT-4 cells assessed as inhibition of viral-induced cytopathogenicity after 4 days by MTT assay	[PMID: 23795238]

Chemical Information

CAS No. 232588-95-3
Molecular Weight 251.24
Formula C₁₁H₁₃N₃O₄
SMILES

N=C1N=C(O)N([C@@H]2O[C@@](CO)(C#C)[C@@H](O)C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Calbert ML, et al. 4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress. Mol Cancer Ther. 2023 Dec 8. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote