N-(Ketocaproyl)-DL-homoserine lactone

Name: N-(Ketocaproyl)-DL-homoserine lactone
Brand: MedChemExpress
SKU: HY-129405
Rating: 4.5 (1 reviews)

Cat. No.: HY-129405 Purity: 98.45%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-(Ketocaproyl)-DL-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer.

For research use only. We do not sell to patients.

N-(Ketocaproyl)-DL-homoserine lactone Chemical Structure

CAS No. : 76924-95-3

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 38	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

N-(Ketocaproyl)-DL-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer^[1].

In Vitro

N-(Ketocaproyl)-DL-homoserine lactone is a natural ligand of Vibrio fischeri as L and D isomers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

213.23

Formula

C₁₀H₁₅NO₄

CAS No.

76924-95-3

Appearance

Solid

Color

White to off-white

SMILES

O=C1OCCC1NC(CC(CCC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (1172.44 mM; Need ultrasonic)

DMSO : 100 mg/mL (468.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6898 mL	23.4489 mL	46.8977 mL
5 mM	0.9380 mL	4.6898 mL	9.3795 mL
10 mM	0.4690 mL	2.3449 mL	4.6898 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (234.49 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.45%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (246 KB) HNMR (257 KB) RP-HPLC (207 KB) LCMS (261 KB)

Handling Instructions (2659 KB)

References

[1]. Li SZ, et al. Influence of the d/l configuration of N-acyl-homoserine lactones (AHLs) and analogues on their Lux-R dependent quorum sensing activity. Bioorg Chem. 2018 Apr;77:215-222. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.6898 mL	23.4489 mL	46.8977 mL	117.2443 mL
	5 mM	0.9380 mL	4.6898 mL	9.3795 mL	23.4489 mL
	10 mM	0.4690 mL	2.3449 mL	4.6898 mL	11.7244 mL
	15 mM	0.3127 mL	1.5633 mL	3.1265 mL	7.8163 mL
	20 mM	0.2345 mL	1.1724 mL	2.3449 mL	5.8622 mL
	25 mM	0.1876 mL	0.9380 mL	1.8759 mL	4.6898 mL
	30 mM	0.1563 mL	0.7816 mL	1.5633 mL	3.9081 mL
	40 mM	0.1172 mL	0.5862 mL	1.1724 mL	2.9311 mL
	50 mM	0.0938 mL	0.4690 mL	0.9380 mL	2.3449 mL
	60 mM	0.0782 mL	0.3908 mL	0.7816 mL	1.9541 mL
	80 mM	0.0586 mL	0.2931 mL	0.5862 mL	1.4656 mL
	100 mM	0.0469 mL	0.2345 mL	0.4690 mL	1.1724 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.