1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog

Nelarabine (Synonyms: 506U78; GW 506U78; Nelzarabine)

Cat. No.: HY-13701 Purity: 99.76%
Handling Instructions

Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. Nelarabine is a chemotherapy drug used in T-cell acute lymphoblastic leukemia.

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Nelarabine Chemical Structure

Nelarabine Chemical Structure

CAS No. : 121032-29-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
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Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
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Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 516 In-stock
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Estimated Time of Arrival: December 31
100 mg USD 634 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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  • Biological Activity

  • Technical Information

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  • References

Description

Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. Nelarabine is a chemotherapy drug used in T-cell acute lymphoblastic leukemia. IC50 Value: 0.44 uM (HSB2 cell lines); 1.24 μM(ALL-SIL cell lines); 2.15 μM(JURKAT cell lines); 0.067 uM (PER-255 cell lines) [1] Target: Nucleoside antimetabolite/analog in vitro: The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively [1]. in vivo: The median age was 34 years (range, 16-66 years); 32 (82%) patients were male. The rate of complete remission was 31% (95% confidence interval [CI], 17%, 48%) and the overall response rate was 41% (95% CI, 26%, 58%). The principal toxicity was grade 3 or 4 neutropenia and thrombocytopenia, occurring in 37% and 26% of patients, respectively [2]. Nelarabine has activity in T-cell malignancies, as evaluated in 2 Phase I and 5 Phase II studies. It received accelerated approval from the FDA based on the resuits of 2 Phase II trials, one in pediatric patients (PGAA 2001) and the other in adults (CALGB 19801) Toxicity: The principal toxicity was grade 3 or 4 neutropenia and thrombocytopenia, occurring in 37% and 26% of patients, respectively [2]. Clinical trial: Drug Use Investigation for Arranon G (Nelarabine) Injection 250 mg.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 9.8 mg/mL (32.97 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3639 mL 16.8197 mL 33.6395 mL
5 mM 0.6728 mL 3.3639 mL 6.7279 mL
10 mM 0.3364 mL 1.6820 mL 3.3639 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

297.27

Formula

C₁₁H₁₅N₅O₅

CAS No.

121032-29-9

SMILES

NC1=NC(OC)=C2N=CN([[email protected]]3[[email protected]]([[email protected]@H]([[email protected]@H](CO)O3)O)O)C2=N1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.76%

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Product Name:
Nelarabine
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HY-13701
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Nelarabine

Cat. No.: HY-13701