1. NF-κB
    Cell Cycle/DNA Damage
    Apoptosis
  2. Keap1-Nrf2
    Topoisomerase
    Apoptosis
  3. Artemisitene

Artemisitene 

Cat. No.: HY-122550
Handling Instructions

Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability.

For research use only. We do not sell to patients.

Artemisitene Chemical Structure

Artemisitene Chemical Structure

CAS No. : 101020-89-7

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Description

Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].

In Vitro

Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

280.32

Formula

C15H20O5

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Artemisitene
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