101020-89-7
101020-89-7
Chemical Structure
Artemisitene
- CAS No.: 101020-89-7
- Formula:C15H20O5
- Molecular Weight:280.32
IUPAC Name: (3R,5aS,6R,8aS,12S,12aR)-3,6-dimethyl-9-methyleneoctahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
InChIKey: IGEBZMMCKFUABB-KPHNHPKPSA-N
SMILES: C=C1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(OO4)[C@@](OC1=O)([H])O[C@@]34C
Biological Activity: Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Artemisitene | 99.93% | Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability. | ||||||||||||||||||||
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References
- [1]. Weimin Chen, et al. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury. FASEB J. 2016 Jul;30(7):2500-10. [Content Brief]
- [2]. Jian Chen, et al. Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway. Oncogene. 2018 Sep;37(37):5079-5087. [Content Brief]
Keywords
