Macrocarpal H 

Macrocarpal H is a natural compound that can be isolated from the Leaves of Eucalyptus globulus. Macrocarpal H exhibits antibacterial activity against Gram-positive cariogenic bacteria and Gram-negative periodontopathic bacteria. Macrocarpal H inhibits adherent water-insoluble glucan synthesis via glucosyltransferase. Macrocarpal H can be used for the research of caries, periodontal disease, dental caries, periodontal disorders^[1][2].

Macrocarpal H (compound 7) (24-48 h) potently inhibits the growth of cariogenic bacteria including S. mutans Ingbritt, S. mutans LA7, S. sobrinus 6715, S. sobrinus B13, and A. viscosus 15987, and periodontopathic bacteria including P. gingivalis 33277, P. melaninogenica 25845, P. intermedia 25611, and C. ochracea 33596, with MIC values ranging from 0.39 to 3.13 µg/mL, and shows weaker activity against F. nucleatum 25586 with an MIC of 6.25 µg/mL^[2].
Macrocarpal H (1-100 µg/mL; 16 h) strongly inhibits glucosyltransferase activity from S. sobrinus 6715, reducing adherent water-insoluble glucan synthesis by 97.6% at 100 µg/mL and 64.0% at 10 µg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

472.61

C₂₈H₄₀O₆

179388-53-5

Solid

Light yellow to yellow

CC(C)C[C@H](C1=C(C(C=O)=C(O)C(C=O)=C1O)O)[C@@]2([H])[C@]3([C@@](C(CC2)=C)([H])C[C@H](C(C)(O)C)CC3)C

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Kenji OSAWA, et al. Configuraitonal and Conformational Analysis of Macrocarpals H, I, and J from Eucalyptus globulus. Chemical and Pharmaceutical Bulletin. 1997, Volume 45, Issue 7, Pages 1216-1217.
  

  [2]. Osawa K, et al. Macrocarpals H, I, and J from the Leaves of Eucalyptus globulus. J Nat Prod. 1996 Sep;59(9):823-7.  [Content Brief]