SLC11A2 Protein, Human (Sf9, His, MBP, FLAG)

The SLC11A2 protein is a proton-coupled metal ion symporter that selectively transports divalent metal cations, including Cd(2+), Fe(2+), Co(2+), Mn(2+), and less Significant Zn(2+), Ni(2+), VO(2+), the stoichiometric ratio of protons and metal ions is 1:1. It is critical for iron homeostasis, regulating intestinal Fe(2+) absorption, transporting TF-associated endosomal Fe(2+), and promoting Fe(2+) and Mn(2+) entry into mitochondria. SLC11A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC11A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC11A2 Protein, Human (Sf9, His, MBP, FLAG) is 567 a.a., .

The SLC11A2 protein, a proton-coupled metal ion symporter, operates with a proton to metal ion stoichiometry of 1:1, selectively transporting various divalent metal cations with varying affinities, including Cd(2+), Fe(2+), Co(2+), Mn(2+), and less significantly Zn(2+), Ni(2+), VO(2+). It plays a crucial role in maintaining iron homeostasis by modulating the intestinal absorption of dietary Fe(2+) and facilitating the transport of TF-associated endosomal Fe(2+) in erythroid precursors and other cells. Additionally, SLC11A2 facilitates the entry of Fe(2+) and Mn(2+) ions into mitochondria, suggesting its involvement in promoting mitochondrial heme synthesis, iron-sulfur cluster biogenesis, and antioxidant defense. Notably, the protein exhibits the ability to mediate uncoupled fluxes of either protons or metal ions, showcasing its versatile transport capabilities.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

P49281 (V2-R568)

4891

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.