[Thr28, Nle31]-Cholecystokinin (25-33), sulfated

Cat. No.: HY-P5519: FAQs
Data Sheet Handling Instructions

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[Thr28, Nle31]-Cholecystokinin (25-33) is a biological active peptide. (Cholecystokinin (CCK) acts both as a hormone and a neurotransmitter and is found in the GI system and the central nervous system. It is a satiety peptide that inhibits food intake.This Cholecystokinin (CCK) analog retains all the bioactivities of CCK8, but was found to be remarkably more stable in acidic media and unaffected by air oxidation due to Met replacements (Thr 28 and Nle31 were substituted for Methionine). The predominant conformation contains a gamma-turn centered on Thr4, separated by Gly5 from a helical segment that comprises the C-terminal residues.)

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[Thr28, Nle31]-Cholecystokinin (25-33), sulfated Chemical Structure

CAS No. : 77568-41-3

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Description	[Thr28, Nle31]-Cholecystokinin (25-33) is a biological active peptide. (Cholecystokinin (CCK) acts both as a hormone and a neurotransmitter and is found in the GI system and the central nervous system. It is a satiety peptide that inhibits food intake.This Cholecystokinin (CCK) analog retains all the bioactivities of CCK8, but was found to be remarkably more stable in acidic media and unaffected by air oxidation due to Met replacements (Thr 28 and Nle31 were substituted for Methionine). The predominant conformation contains a gamma-turn centered on Thr4, separated by Gly5 from a helical segment that comprises the C-terminal residues.)
Molecular Weight	1251.32
Formula	C₅₅H₇₄N₁₄O₁₈S
CAS No.	77568-41-3
Sequence	Arg-Asp-{Tyr(SO3H)}-Thr-Gly-Trp-{Nle}-Asp-Phe-NH2
Sequence Shortening	RD-{Tyr(SO3H)}-TGW-{Nle}-DF-NH2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (233 KB) Handling Instructions (2659 KB)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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[Thr28, Nle31]-Cholecystokinin (25-33), sulfated77568-41-3OthersInhibitorinhibitorinhibit

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[Thr28, Nle31]-Cholecystokinin (25-33), sulfated